Leptin, adiponectin, and resistin blood adipokine levels in migraineurs: Systematic reviews and meta-analyses

Cephalalgia : an International Journal of Headache
Milad AbbasiSajjad Panahi

Abstract

Migraine comorbidity with obesity is not new and studies have focused on how adipose tissue-derived substances such as adipokines might be involved in the migraine pathophysiology. Quantification of the nature and magnitude of the association between each adipokine including leptin, adiponectin and resistin with migraine pathophysiology is the objective of the current study. Using systematic reviews and meta-analyses and standardized mean difference as effect size, the levels of three adipokines, leptin, adiponectin and resistin, have been investigated in migraineur subjects in the case-control studies. Using random-effects models, the final analyses demonstrated the standardized mean differences of leptin, adiponectin and resistin as 0.534 (95% confidence interval, 0.169-0.898), 0.439 (95% confidence interval, 0.132-0.746) and 0.194 (95% confidence interval, -0.158-0.546), respectively. The p-value for test of significance for each pooled standardized mean difference was examined by the z-test and calculated as 0.004, 0.005 and 0.281 for leptin, adiponectin and resistin (clearly considered as statistically significant, significant and non-significant), respectively. Based on the findings, the blood levels of leptin and adipone...Continue Reading

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Citations

Jan 29, 2021·Frontiers in Psychiatry·Jinfeng DuanChenxia Hu
Aug 19, 2021·Cephalalgia : an International Journal of Headache·Yu-Chien TsaoCathy Shen-Jang Fann

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

PRISMA
Stata

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