Leptin affects prolactin action on milk protein and fat synthesis in the bovine mammary gland

Journal of Dairy Science
Y FeuermannA Shamay

Abstract

Leptin, a protein hormone produced and secreted predominantly by white adipose tissue, has a critical role in the regulation and coordination of energy metabolism. Identification of leptin in the milk of several mammals, including humans, led us to investigate its presence and regulatory effect in the cow mammary gland. The expression of leptin receptor in tissue culture of lactating mammary gland was augmented approximately 25 times by prolactin, but had no effect on virgin calf mammary tissue. Expression of leptin in tissue culture from mammary glands of lactating cows was enhanced 2.2-fold by prolactin. No effect of prolactin on leptin and leptin receptor expression was found in mammary gland tissue culture from calves. Leptin-enhanced fatty acid synthesis in the presence of prolactin, but had no effect without presence of prolactin. A similar pattern was found in the expression of alpha-casein and beta-lactoglobulin in mammary gland explants from a lactating cow. Our findings indicate that leptin plays an important role in mammary gland lactogenesis, and that the expression of leptin requires the presence of prolactin.

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Citations

Jan 6, 2010·International Journal of Endocrinology·Yonatan FeuermannAvi Shamay
Oct 4, 2005·Domestic Animal Endocrinology·Shinichi YonekuraYoshiaki Obara
May 23, 2007·Journal of Dairy Science·J Szyda, J Komisarek
Oct 24, 2008·Journal of Dairy Science·Y FeuermannS J Mabjeesh
Jun 12, 2013·Journal of Dairy Science·R GambraH Khatib
Sep 20, 2007·Science in China. Series C, Life Sciences·Ye Lin, QingZhang Li
Mar 18, 2010·The Journal of Veterinary Medical Science·Tomoya YamadaNaoto Nakanishi
Jul 28, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·John R Speakman, Elzbieta Król
Jun 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Deenaz ZaidiGraham F Wagner
Mar 2, 2016·Scientific Reports·Daniella C BuonfiglioJose Donato
Mar 8, 2012·Tropical Animal Health and Production·Tushar TanpureRanjit Singh Kataria
Aug 4, 2021·Reproductive Toxicology·Thalles Fernando Rocha RuizEllen Cristina Rivas Leonel

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