Leptin affects the electrical activity of neurones in the hypothalamic supraoptic nucleus

Brain Research Bulletin
Kazumasa HondaT Higuchi

Abstract

The present experiments were undertaken to examine whether leptin affects the electrical activity of neurones in the supraoptic nucleus (SON) by using brain slice preparation of male Wistar and obese Zucker rats. Bath application of leptin (10(-8) - 10(-12) M) induced mainly inhibitory response in SON neurones of Wistar rats, although a minority showed excitation. These effects were observed in both continuously and phasically active cells. The inhibitory effect of leptin still persisted in low Ca(2+), high Mg(2+) medium. Bath application of tolbutamide, which is known to inhibit ATP-sensitive potassium channel activity, did not reverse the inhibitory effect of leptin on SON neurones. The effect of bath application of leptin was also tested in SON neurones of obese Zucker rats. Although leptin still affected the electrical activity of some SON neurones of Zucker rats, the proportion of unaffected neurones was significantly higher than in Wistar rats. The results suggest that leptin may inhibit the secretion of both oxytocin and vasopressin by inhibiting the electrical activity of neurones in the SON via direct action. This inhibitory effect of leptin may be exerted through mechanisms other than activation of ATP-sensitive potas...Continue Reading

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Citations

May 26, 2004·Physiology & Behavior·Rexford S Ahima, Suzette Y Osei
Jul 12, 2005·Biochemical and Biophysical Research Communications·Nicola PatanoAlberta Zallone
Sep 23, 2008·The Journal of Comparative Neurology·Christoph RummelGiamal N Luheshi
Aug 25, 2015·Frontiers in Endocrinology·Jordi AltirribaFrançoise Rohner-Jeanrenaud
Aug 1, 2006·Progress in Brain Research·Rexford S AhimaNeel S Singhal
Feb 17, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tzu-Ling LiLing-Ling Hwang
Jan 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Véronique BreuilEz-Zoubir Amri
Jan 31, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zhilin SongCelia D Sladek
Nov 12, 2003·Experimental Biology and Medicine·Katsuhiko NagamoriKazuo Sasaki
Sep 25, 2002·Biochemical and Biophysical Research Communications·Silvia ColucciAlberta Zallone
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans

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