Leptin and camel milk abate oxidative stress status, genotoxicity induced in valproic acid rat model of autism

International Journal of Immunopathology and Pharmacology
Mohamed A HamzawyZoba H Ali

Abstract

The aspect of treatment of autistic behaviour was investigated using valproic acid rat model of pregnant female rats. Two main groups (10 male rats/group) were treated for 6 days and then divided into six subgroups. The first group of normal rats was divided into three subgroups: (A) - control group, (B) - treated with camel milk (CAM; 2 mL/p.o) and (C) - treated with leptin (1000 µg/kg i.p) twice daily. The second group of autistic rats was randomly distributed into four subgroups as follows: (D) - positive control (autistics rats), (E) - treated with CAM, (F) - treated with a moderate dose of leptin and (G) - treated with a higher dose of leptin. Autistic behaviours of male offspring were checked by grooming and elevated pulz maze tests. Valproic acid (VPA)-induced autistic rats showed severe changes in oxidative stress markers, neurotransmitters and inflammatory cytokines, besides genotoxic manifestation of expression of tumour necrosis factor (TNF)-α, Bax and caspase-3. Leptin or CAM alone showed no signs of toxicity. CAM showed pronounced improvement in control rats than control itself. Leptin or CAM treatment of autistic animals showed a significant improvement of all measured parameters and genetic expression values. The...Continue Reading

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Citations

Sep 7, 2018·BMC Neuroscience·Laura Mora-MuñozAlberto Velez-van-Meerbeke
Dec 16, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yasmina M Abd-ElhakimMostafa A Shalaby

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Methods Mentioned

BETA
electrophoresis
PCR
MDA

Software Mentioned

Gel
Pro
Statistical Analysis System ( SAS

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