Leptin and fractalkine: novel subcutaneous cytokines in burn injury.

Disease Models & Mechanisms
Dominic FristonIstvan Nagy

Abstract

Burn injury is a pathology underpinned by progressive and aberrant inflammation. It is a major clinical challenge to survival and quality of life. Although the complex local and disseminating pathological processes of a burn injury ultimately stem from local tissue damage, to date relatively few studies have attempted to characterise the local inflammatory mediator profile. Here, cytokine content and associated transcriptional changes were measured in rat skin for three hours immediately following induction of a scald-type (60°C, 2 min) burn injury model. Leptin (P=0.0002) and fractalkine (P=0.0478) concentrations were significantly elevated post-burn above pre-burn and control site values, coinciding with the development of burn site oedema and differential expression of leptin mRNA (P=0.0004). Further, gene sequencing enrichment analysis indicated cytokine-cytokine receptor interaction (P=1.45×10-6). Subsequent behavioural studies demonstrated that, following subcutaneous injection into the dorsum of the paw, both leptin and fractalkine induced mechanical allodynia, heat hyperalgesia and the recruitment of macrophages. This is the first report of leptin elevation specifically at the burn site, and the first report of fractalk...Continue Reading

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Citations

Jan 13, 2021·Scientific Reports·Elisabeth HofmannPetra Kotzbeck

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Datasets Mentioned

BETA
GSE102811

Methods Mentioned

BETA
RNA-seq
biopsies

Software Mentioned

gage
Origin
Matlab
Limma
HTSeq
R
edgeR
xPONENT
Leica Application Suite
ARRIVE

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