Leptin and Lipid Profile in Overweight Patient with Type 1 Diabetes

Open Access Macedonian Journal of Medical Sciences
Soha M Abd El DayemEman Abd El Megeed

Abstract

To evaluate leptin and lipid profile in overweight patients with type 1 diabetes. The study included 50 overweight patients with type 1 diabetes and 50 age and sex matched healthy controls. Blood samples were taken for evaluation of glycosylated haemoglobin, lipid profile and leptin. Also, urine samples were taken for evaluation of albumin/creatinine ratio. Leptin level was significantly lower in overweight with type 1 diabetes and showed a significant positive correlation with hip circumference and body mass index and negative correlation with glycosylated haemoglobin (HbA1c). Leptin level was significantly lower in overweight diabetic patients with HbA1c > 7.5 %. The best cut-off point between overweight diabetic group and control group regarding leptin levels was found at 16.9 (ng/ml) with a sensitivity of 68% and specificity of 56%, area under the curve 0.623. Leptin levels were found to be low in overweight patients with type 1 diabetes and showed correlation with the body mass index and hip circumference. LDL was significantly higher while HDL was significantly lower in the diabetic, overweight group indicating increased risk of cardiovascular disease. Leptin level in overweight diabetic patients might be related to the m...Continue Reading

References

Feb 18, 1971·The New England Journal of Medicine·L A TrivelliH T Lai
Feb 9, 1984·The New England Journal of Medicine·C E Mogensen
Aug 14, 1998·European Journal of Endocrinology·A VerrottiF Chiarelli
Dec 30, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·W H HermanE M el Behairy
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Susan P LaingHarry Keen
Dec 4, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S E MooreA M Prentice
Oct 14, 2004·The Journal of Pediatrics·Jody S KrantzFrancine R Kaufman
Jan 12, 2005·FEBS Letters·Miguel OteroOreste Gualillo
Apr 11, 2006·Preventive Cardiology·Ana Marice LadeiaArmênio C Guimarães
Nov 23, 2006·Diabetes Research and Clinical Practice·Rimei NishimuraNaoko Tajima
Jan 11, 2007·Pediatric Diabetes·Maria E CraigUNKNOWN International Society for Pediatric and Adolescent Diabetes
Jan 24, 2007·The Journal of Pediatrics·David M MaahsGeorgeanna J Klingensmith
Jan 16, 2008·Diabetologia·H D MargeirsdottirUNKNOWN Norwegian Study Group for Childhood Diabetes
Jul 3, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Spiros FourlanosPeter G Colman
Aug 30, 2008·The British Journal of Nutrition·Henedina AntunesSusana Carvalho
Jan 15, 2010·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Mar 13, 2010·The Journal of Pediatrics·Mariska van VlietHenk J Veeze
Apr 8, 2010·The Journal of Clinical Endocrinology and Metabolism·Janet K Snell-BergeonDana Dabelea
Aug 1, 2009·Journal of Clinical Lipidology·Awatif M Abd El-MaksoudIbrahim H Kamal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.