PMID: 11898393Mar 20, 2002Paper

Leptin and sweet taste

Vitamins and Hormones
Yuzo NinomiyaBernd Lindemann

Abstract

Leptin, the product of the obese (ob) gene, is a hormone primarily produced in adipose cells, and also at smaller amounts in some other peripheral organs. It regulates food intake, energy expenditure, and body weight. Leptin is thought to promote weight loss, at least in rodents, by suppressing appetite and stimulating metabolism. Mutant mice that lack either leptin or functional leptin receptors, such as ob/ob and db/db mice, are hyperphagic, massively obese, and diabetic. Central hypothalamic targets are mainly responsible for the effects of leptin on food intake and weight loss. However, there are also direct effects on peripheral tissues. Recently, the taste organ was found to be one of the peripheral targets for leptin. The hormone specifically inhibits sweet taste responses in lean mice and not in db/db mice. Thus leptin appears to act as a modulator of sweet taste, provided a functional leptin receptor is expressed by the taste cells. This chapter reviews the genetics and molecular biology of leptin and its receptors, the receptor mechanisms for sweet taste, the modulating action of leptin on taste receptor cells, and the consequences for the regulation of food intake.

Citations

Mar 14, 2003·Journal of Neurophysiology·Yasutake ShimizuKeiichi Tonosaki
Sep 16, 2008·Cell and Tissue Research·Nicole HassKarin Schwarzenbacher
May 1, 2010·Endocrine Journal·Masafumi JyotakiYuzo Ninomiya
Oct 22, 2010·Nutrition Reviews·Paul A M SmeetsCees de Graaf
Mar 16, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J-P ChaputA Tremblay
Aug 19, 2009·Annals of the New York Academy of Sciences·Keisuke SanematsuYuzo Ninomiya
Feb 22, 2011·Angewandte Chemie·Maik BehrensThomas Hofmann
May 3, 2008·Internal Medicine·Yoshihiko NakazatoKunio Shimazu
May 30, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Hanrui ZhangCuihua Zhang
Sep 15, 2001·Nature·B Lindemann
May 20, 2011·Journal of Anatomy·Flavia MerigoAndrea Sbarbati
Feb 15, 2007·European Journal of Clinical Nutrition·F Bellisle, A Drewnowski
Jul 10, 2021·Frontiers in Human Neuroscience·Elena von MolitorTiziana Cesetti

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