PMID: 8962092Dec 10, 1996Paper

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

Proceedings of the National Academy of Sciences of the United States of America
T GainsfordD J Hilton

Abstract

Many cytokines exert their biological effect through members of the hemopoietin receptor family. Using degenerate oligonucleotides to the common WSXWS motif, we have cloned from human hemopoietic cell cDNA libraries various forms of the receptor that was recently shown to bind the obesity hormone, leptin. mRNAs encoding long and short forms of the human leptin receptor were found to be coexpressed in a range of human and murine hemopoietic organs, and a subset of cells from these tissues bound leptin at the cell surface. Ectopic expression in murine Ba/F3 and M1 cell lines revealed that the long, but not the short, form of the leptin receptor can signal proliferation and differentiation, respectively. In cultures of murine or human marrow cells, human leptin exhibited no capacity to stimulate cell survival or proliferation, but it enhanced cytokine production and phagocytosis of Leishmania parasites by murine peritoneal macrophages. Our data provide evidence that, in addition to its role in fat regulation, leptin may also be able to regulate aspects of hemopoiesis and macrophage function.

References

Feb 1, 1992·Trends in Biochemical Sciences·D J Hilton
Sep 11, 1990·Nucleic Acids Research·S Mizushima, S Nagata
Dec 1, 1990·Immunology Today·T HiranoT Kishimoto
Jul 1, 1990·Trends in Biochemical Sciences·D CosmanC J March
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J F Bazan
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D J HiltonD Metcalf
Sep 1, 1988·Analytical Biochemistry·D J HiltonD Metcalf
Dec 1, 1969·Journal of Cellular Physiology·Y Ichikawa
Dec 13, 1972·Nature: New Biology·B M Sultzer, B S Nilsson
Feb 1, 1983·Molecular and Biochemical Parasitology·E HandmanT W Spithill
Dec 1, 1994·Acta Paediatrica·D Fugelseth, R Lindemann
Jan 28, 1994·Cell·T KishimotoS Akira
Jan 11, 1996·Nature·J Scott
Dec 29, 1995·Cell·L A TartagliaR I Tepper
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·D J HiltonT A Willson
Feb 16, 1996·Science·M Barinaga
Feb 15, 1996·Nature·G H LeeJ M Friedman
May 1, 1996·Nature Genetics·M S PhillipsJ F Hess

❮ Previous
Next ❯

Citations

Jul 13, 2000·Microscopy Research and Technique·B N Finck, R W Johnson
Feb 15, 2001·Journal of Cellular Physiology·B CousinL Pénicaud
May 2, 2009·Inflammatory Bowel Diseases·A BatraB Siegmund
Feb 17, 2000·Cellular Immunology·C Martín-RomeroV Sánchez-Margalet
Aug 28, 1999·Molecular Biotechnology·T Gainsford, W S Alexander
Jan 7, 2003·International Journal of Hematology·Heike WexPeter Vorwerk
Sep 12, 2002·Journal of Physiology and Biochemistry·C BértoloM P Lostao
Jul 26, 2003·Eating and Weight Disorders : EWD·C CalandraR Musso
Apr 20, 2007·Rheumatology International·Margaret WisłowskaMałgorzata Cicha
Jan 16, 2008·Rheumatology International·M WisłowskaA Kuklo-Kowalska
May 19, 2006·Histochemistry and Cell Biology·Hong Ping ChenSheng Cui
Aug 8, 2007·Histochemistry and Cell Biology·Marco R SchroeterKatrin Schäfer
Feb 23, 2011·Histochemistry and Cell Biology·Shinji IdeKazuhito Satomura
Aug 30, 2008·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Safdar N KhanAaron Daluiski
Jun 2, 2005·Diabetes Research and Clinical Practice·Masanori NakataToshihiko Yada
Mar 30, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E BugianesiG Marchesini
Oct 5, 2013·Peptides·Carol C DiasEdgar J Paredes-Gamero
May 15, 2002·European Journal of Pharmacology·Daniel W LeePatricia Grasso
Feb 13, 1999·European Journal of Pharmacology·T TsuchiyaM Mori
Mar 29, 2003·Mechanisms of Ageing and Development·John K ScarianoRichard N Baumgartner
Mar 21, 1998·Lancet·J Auwerx, B Staels
Feb 5, 2000·Journal of Reproductive Immunology·S N HudsonS A Robertson
Aug 1, 1997·Trends in Neurosciences·M F Mehler, J A Kessler
Oct 12, 2000·Regulatory Peptides·C M SteppanA G Swick
Mar 1, 2003·Regulatory Peptides·M Friedman-EinatA D Strosberg
Apr 11, 2003·Regulatory Peptides·Mario BarattaCarlo Tamanini
Jun 18, 1997·Regulatory Peptides·K IshidaK Shima
Apr 28, 2001·Molecular and Cellular Endocrinology·C C GerhardtA D Strosberg
May 9, 2002·Molecular and Cellular Endocrinology·O GualilloF F Casanueva
Sep 21, 2002·Molecular and Cellular Endocrinology·Cristiana E Juge-Aubry, Christoph A Meier
Apr 23, 2003·Molecular and Cellular Endocrinology·P MaroniR Piccoletti
Jan 5, 2000·Molecular and Cellular Endocrinology·L Berti, S Gammeltoft
Mar 18, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Thierry Thomas
May 1, 2002·Comptes rendus biologies·Olivier CamandMichèle Guerre-Millo
Mar 15, 2012·The Proceedings of the Nutrition Society·J Justin Milner, Melinda A Beck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.