Leptin concentrations are a predictor of overweight reduction in a lifestyle intervention

International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity
Thomas ReinehrWerner Andler

Abstract

Leptin resistance is discussed to be involved in the genesis of obesity. Therefore, we hypothesized that leptin levels were negatively associated with degree of weight loss in obese children participating in a lifestyle intervention. We studied 248 obese children aged 8-14 years attending the "Obeldicks" lifestyle intervention (mean age 10.6+/-0.2 years, 53% female, 48% pubertal, mean body mass index (BMI) 27.8+/-0.3 kg/m2, and mean standard deviation score [SDS]-BMI 2.43+/-0.03). Baseline leptin concentrations were correlated with change of weight status, waist circumference, and percentage body fat, as calculated from skinfold measurements in the one-year intervention by Pearson correlation and multiple linear regression analyses. Furthermore, the relationship between leptin and cardiovascular risk factors (insulin, insulin resistance index HOMA, blood pressure, lipids, and glucose) were analyzed. A total of 212 children (85%) reduced their overweight, 9 children (4%) dropped out, and 27 children (11%) did not reduce their overweight in the lifestyle intervention "Obeldicks". The mean reduction of SDS-BMI was 0.34+/-0.02. The reduction of SDS-BMI (r=- 0.27), waist circumference (r=- 0.64), and percentage body fat (r=- 0.26) w...Continue Reading

Citations

Sep 30, 2010·Metabolic Syndrome and Related Disorders·Meiju SaukkoOlavi Ukkola
Jan 6, 2012·Metabolic Syndrome and Related Disorders·Aaron S KellyJulia Steinberger
Aug 31, 2011·Pakistan Journal of Biological Sciences : PJBS·Mahmoud Abu-SamakRula Khuzaie
Sep 1, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B G P KootM A Benninga
Sep 7, 2016·Archives of Endocrinology and Metabolism·Isabel MadeiraRebeca Ribeiro
Jun 13, 2018·International Journal of Experimental Pathology·Zayani NesrineBouslama Ali
Oct 12, 2010·American Journal of Physiology. Renal Physiology·Abdul Bari MuhammadAnees A Banday
May 7, 2011·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·S WiegandB Babitsch
Nov 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Alexandra E KullePaul-Martin Holterhus

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