Leptin concentrations in the polycystic ovary syndrome

The Journal of Clinical Endocrinology and Metabolism
C S MantzorosJ S Flier

Abstract

The polycystic ovary syndrome (PCOS) is characterized by menstrual disturbances, chronic anovulation and hyperandrogenism and is associated with insulin resistance and hyperinsulinemia. Leptin, the product of the ob gene, is an adipocyte-secreted molecule that signals the magnitude of energy stores to the brain and has been recently shown to have important effects on the reproductive axis of rodents. To assess the potential contribution of leptin to the pathogenesis of PCOS, we measured leptin levels in 24 obese women with PCOS and 12 weight- and age-matched controls and determined whether alterations in hyperinsulinemia produced by administration of the insulin-sensitizing agent troglitazone had an effect on serum leptin levels. Leptin concentrations at baseline were not different in women with PCOS (38.1 +/- 2.15 ng/mL) and controls (33.12 +/- 2.39 ng/mL). Moreover, leptin concentrations remained unchanged after treatment with troglitazone (38.1 +/- 2.15 vs. 39.21 +/- 2.65 ng/mL). Baseline leptin correlated strongly with body mass index in both controls (r = 0.59; P < 0.05) and women with PCOS (r = 0.70; P = 0.0004). Leptin levels were not associated with baseline insulin, testosterone, non-sex hormone-binding globulin (SHBG)...Continue Reading

References

Oct 1, 1995·The Journal of Clinical Investigation·D S WeigleJ L Kuijper
Oct 1, 1995·The American Journal of Medicine·M B Davidson
Jul 28, 1995·Science·M A PelleymounterF Collins
Sep 28, 1995·The New England Journal of Medicine·S Franks
Sep 1, 1995·The Journal of Clinical Investigation·R C FrederichJ S Flier
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Feb 1, 1996·The New England Journal of Medicine·F Rohner-Jeanrenaud, B Jeanrenaud
Apr 25, 1996·Nature·S CollinsR S Surwit
Feb 15, 1996·Nature·G H LeeJ M Friedman
Jun 1, 1996·Diabetes·S M HaffnerR L Gingerich
Mar 1, 1996·The Journal of Clinical Investigation·M K SinhaJ F Caro
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·C B Kallen, M A Lazar
Jul 18, 1996·Nature·R S AhimaJ S Flier
Jul 1, 1996·Endocrinology·I A BarashR A Steiner
Nov 1, 1996·Diabetes·J F CaroR V Considine
Nov 1, 1996·Cell·B M Spiegelman, J S Flier

❮ Previous
Next ❯

Citations

Dec 14, 2004·Journal of Assisted Reproduction and Genetics·Hisham Ali SalehEbtehag Mohamed Eldaqaq
Mar 4, 1998·Proceedings of the National Academy of Sciences of the United States of America·J LicinioP W Gold
Oct 10, 1998·Journal of Endocrinological Investigation·M P Leondires, S L Berga
Mar 23, 2011·Current Diabetes Reports·Jennifer Villa, Richard E Pratley
Aug 2, 2012·Cellular and Molecular Life Sciences : CMLS·Carol F Elias, Darshana Purohit
Apr 27, 2007·Nihon rinsho. Japanese journal of clinical medicine·Ken Ebihara
Jul 17, 2015·International Journal of Endocrinology·Nasser M Rizk, Elham Sharif
Jul 18, 2018·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Eduardo MerloJones B Graceli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.