Leptin deficiency causes pycnotic change in fetal cingulate cortical cells

Congenital Anomalies
Jun UdagawaHiroki Otani

Abstract

Leptin is an obese gene product, and leptin-deficient ob/ob mice develop hyperphagia and reduced locomotor activity. Leptin is thought to be related to brain development, because leptin receptors are widely expressed in the brain, and because brain weight as well as brain protein and DNA contents were reduced in adult ob/ob mice. In this study, we investigated the effect of leptin on the fetal cingulate cortex, since the leptin receptor is expressed in the neurons of the cingulate cortex, which is involved in emotion as well as in sensory, motor, and cognitive processes. The ob/ob fetuses had more pycnotic cells than wild-type fetuses in the cingulate cortex at embryonic day (E) 18. Many pycnotic cells were observed in the intermediate zone of the cingulate cortex. Most cells observed in this area were neuronal lineage cells, while few undifferentiated cells and oligodendrocyte precursor cells were found. At E18 there was no significant difference in the rostrocaudal length of the corpus callosum, which contains the neuronal projection from the cingulate cortex, between ob/ob and wild-type fetuses. We also showed that the length of the cerebrum was greater and the width of the cerebrum and cerebellum were lesser in ob/ob fetuse...Continue Reading

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Citations

Jan 11, 2007·Clinical Medicine & Research·Delia-Marina AlexeEleni Th Petridou
Aug 11, 2007·Congenital Anomalies·Jun UdagawaHiroki Otani
Feb 11, 2009·Cell Biochemistry and Function·Yusuf Ziya ZiylanRasim Mogulkoc
Jan 10, 2009·Biochimica Et Biophysica Acta·Christopher D Morrison
May 21, 2011·Psychosomatic Medicine·Melanie L Zupancic, Aman Mahajan
Apr 28, 2021·Progress in Neurobiology·Navneet A Vasistha, Konstantin Khodosevich

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