Leptin deficiency enhances myocardial necrosis and lethality in a murine model of viral myocarditis

Life Sciences
T KandaNoboru Takekoshi

Abstract

To investigate the role of leptin in the development of viral myocarditis and cardiac necrosis, we used a murine model of viral myocarditis. We intraperitoneally injected encephalomyocarditis virus (500 plaque-forming units/mouse) for wild type C57 BL/6 mice (WT) and leptin-deficient ob/ob mice (OB) (n = 20 for each). Ten-day survival rate was 25% in OB, whereas it was 95% in WT. Heart weights on day 10 were significantly elevated in OB compared with those in WT (107.2 +/- 9.4 vs. 96.6 +/- 7.9 mg, n = 4 for each). Thymus weights were significantly diminished in OB compared with those in WT on days 6 and 10. Histological score (grade 1 to 4 according to the size of involved area) for myocardial necrosis were significantly higher in OB than in WT (1.5 +/- 0.5 vs. 0.8 +/- 0.5, n = 4 for each). On day 4, viral titer in hearts was significantly elevated in OB compared with that in WT (3.3 +/- 0.5 vs. 1.9 +/- 0.2 TCID50/mg, n = 3 for each). Comparative expression of TNF-alpha mRNA in hearts from OB were significantly increased compared with those in WT on day 7 (n = 3 for each). Natural killer cell activities in spleens from OB were significantly lower than from WT on day 4 (27 +/- 5 vs. 42 +/- 8%, n = 4 for each). Thus, leptin defic...Continue Reading

References

May 1, 1996·Circulation Research·T KandaI Kobayashi
Jul 14, 1998·The Journal of Clinical Endocrinology and Metabolism·K K MillerS K Grinspoon
Apr 24, 1999·Annals of Internal Medicine·C S Mantzoros
Dec 13, 2000·Journal of Molecular and Cellular Cardiology·T KandaI Kobayashi
Aug 24, 2002·Archives of Disease in Childhood·S E MooreA M Prentice
Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Bernhard MaischSabine Pankuweit
Feb 1, 2003·European Journal of Heart Failure·P Christian SchulzeGerhard Schuler

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Citations

Feb 24, 2009·Cardiovascular Research·Kenneth R McGaffinChristopher P O'Donnell
Nov 19, 2009·Circulation. Heart Failure·Kenneth R McGaffinCharles F McTiernan
Feb 16, 2006·International Heart Journal·Takashi TakahashiTsugiyasu Kanda
Dec 27, 2015·Neuropeptides·Eliska MistrovaMagdalena Chottova Dvorakova
Dec 17, 2015·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhao LiuZhan-Qiu Yang
Sep 27, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Haibo WangSiwang Wang
May 26, 2007·The American Journal of Pathology·Arvind BatraBritta Siegmund
Nov 7, 2012·Journal of Cellular Physiology·Bruno LamasMarie-Chantal Farges
Dec 21, 2013·Journal of cardiology·Kazuto NakamuraKenneth Walsh
Mar 31, 2015·BioMed Research International·Prema RobinsonGohar Firozgary
Dec 4, 2010·Experimental Biology and Medicine·Erik A Karlsson, Melinda A Beck
Mar 26, 2005·The Journal of International Medical Research·T TakahashiT Kanda
Sep 29, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christiane D WrannHeike Nave
Sep 4, 2009·Disease Models & Mechanisms·Heiko Bugger, E Dale Abel

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