Leptin deficiency-induced obesity exacerbates ultraviolet B radiation-induced cyclooxygenase-2 expression and cell survival signals in ultraviolet B-irradiated mouse skin

Toxicology and Applied Pharmacology
Som D Sharma, Santosh K Katiyar

Abstract

Obesity has been implicated in several inflammatory diseases and in different types of cancer. Chronic inflammation induced by exposure to ultraviolet (UV) radiation has been implicated in various skin diseases, including melanoma and nonmelanoma skin cancers. As the relationship between obesity and susceptibility to UV radiation-caused inflammation is not clearly understood, we assessed the role of obesity on UVB-induced inflammation, and mediators of this inflammatory response, using the genetically obese (leptin-deficient) mouse model. Leptin-deficient obese (ob/ob) mice and wild-type counterparts (C57/BL6 mice) were exposed to UVB radiation (120 mJ/cm(2)) on alternate days for 1 month. The mice were then euthanized and skin samples collected for analysis of biomarkers of inflammatory responses using immunohistochemistry, western blotting, ELISA and real-time PCR. Here, we report that the levels of inflammatory responses were higher in the UVB-exposed skin of the ob/ob obese mice than those in the UVB-exposed skin of the wild-type non-obese mice. The levels of UVB-induced cyclooxygenase-2 expression, prostaglandin-E(2) production, proinflammatory cytokines (i.e., tumor necrosis factor-alpha, interleukin-1beta, interleukin-6)...Continue Reading

References

Mar 1, 1988·The Journal of Investigative Dermatology·V A TronD N Sauder
Apr 1, 1996·Current Opinion in Cell Biology·C L Carpenter, L C Cantley
Feb 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R M Tyrrell
Apr 1, 1996·Photochemistry and Photobiology·H Mukhtar, C A Elmets
Apr 30, 1998·Current Opinion in Cell Biology·J Downward
May 25, 1999·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·F MarksK Müller-Decker
Sep 15, 1999·Nature·J A Romashkova, S S Makarov
Jan 12, 2000·Oncogene·C S WilliamsR N DuBois
Feb 10, 2000·The American Journal of Pathology·K S ChappleM A Hull
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Oct 9, 2002·JAMA : the Journal of the American Medical Association·Katherine M FlegalClifford L Johnson
Oct 9, 2002·JAMA : the Journal of the American Medical Association·Cynthia L OgdenClifford L Johnson
Jan 17, 2003·The Journal of Biological Chemistry·Carine ChaveySophie Tartare-Deckert
Oct 31, 2003·Cancer Cell·Ji LuoLewis C Cantley
Nov 13, 2003·Seminars in Oncology·Gordon B MillsGabriel Hortobagyi
Dec 18, 2003·The Journal of Clinical Investigation·Haiyan XuHong Chen
Jun 17, 2004·JAMA : the Journal of the American Medical Association·Allison A HedleyKatherine M Flegal
Dec 27, 2006·Free Radical Biology & Medicine·Santosh K Katiyar, Syed M Meeran
May 30, 2008·The Journal of Investigative Dermatology·Syed M MeeranSantosh K Katiyar
Nov 4, 2008·Biological Chemistry·Elena Roza Motrescu, Marie-Christine Rio
Sep 17, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rob C M van KruijsdijkFrank L J Visseren

❮ Previous
Next ❯

Citations

Nov 5, 2011·The Proceedings of the Nutrition Society·Suzanne L DoyleJohn V Reynolds
Mar 28, 2012·Cancer Causes & Control : CCC·Salma PothiawalaJiali Han
Jul 23, 2013·International Journal of Dermatology·Anne-Marie TobinBrian Kirby
Nov 19, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J Chen
Apr 5, 2013·Journal of Cellular Biochemistry·Jiezhong ChenXu Dong Zhang
May 14, 2011·The British Journal of Dermatology·A R Shipman, G W M Millington
Nov 11, 2016·Reviews in Endocrine & Metabolic Disorders·K KarimiRobert T Brodell
Feb 22, 2017·Pigment Cell & Melanoma Research·Emily ClementLaurence Nieto
Jan 2, 2014·Therapeutic Advances in Gastroenterology·Claire L DonohoeJohn V Reynolds
Feb 19, 2020·International Journal of Epidemiology·Jean Claude DusingizeDavid C Whiteman
Aug 17, 2012·Cancer Prevention Research·Tricia MooreJohn DiGiovanni
Nov 15, 2020·Nutrients·Nevena SkrozaConcetta Potenza
Mar 16, 2021·Annals of Surgical Oncology·Constance S Harrell ShreckengostMichael C Lowe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.