Leptin Elevation as a Risk Factor for Slipped Capital Femoral Epiphysis Independent of Obesity Status

The Journal of Bone and Joint Surgery. American Volume
Schuyler J HalversonJonathan G Schoenecker

Abstract

Slipped capital femoral epiphysis (SCFE) is strongly associated with childhood obesity, yet the prevalence of obesity is orders of magnitude greater than the prevalence of SCFE. Therefore, it is hypothesized that obesity is not, by itself, a sufficient condition for SCFE, but rather one component of a multifactorial process requiring preexisting physeal pathology. Leptin elevation is seen to varying degrees in patients with obesity, and as leptin has been shown to cause physeal pathology similar to the changes seen in SCFE, we propose that leptin may be a factor distinguishing between patients with SCFE and equally obese children without hip abnormalities. Serum leptin levels were obtained from 40 patients with SCFE and 30 control patients with approximate body mass index (BMI) matching. BMI percentiles were calculated according to Centers for Disease Control and Prevention population data by patient age and sex. Patients were compared by demographic characteristics, leptin levels, odds of leptin elevation, and odds of SCFE. The odds of developing SCFE was increased by an odds ratio of 4.9 (95% confidence interval [CI], 1.31 to 18.48; p < 0.02) in patients with elevated leptin levels, regardless of obesity status, sex, and race...Continue Reading

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Citations

Feb 21, 2018·The Journal of Bone and Joint Surgery. American Volume·Derek M KellyJeffrey E Martus
Mar 20, 2018·Journal of Pediatric Orthopedics·Matthew R SchmitzWudbhav N Sankar
Mar 26, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ata M KiapourEduardo N Novais
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Jul 8, 2021·Journal of Pediatric Orthopedics·Jennifer J BeckBarbara Minkowitz
Oct 24, 2018·Pediatrics·Daniel C PerrySteven Turner

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