Leptin, hsCRP, TNF-α and IL-6 levels from normal aging to dementia: Relationship with cognitive and functional status.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Carolina A MagalhãesKarina B Gomes

Abstract

Cognitive impairment, including mild cognitive impairment (MCI) and dementia, compromises the patients' cognitive abilities and, to different extents, to carry out daily activities, accompanied by personality and behavioral changes. Studies suggest that leptin, an adipokine, has a neuroprotective role against Alzheimer's disease (AD) and that cytokines are associated with inflammatory processes and dementia. This study aimed to evaluate serum leptin, hsCRP, IL-6 and TNF-α levels in a cognitive continuum group from normal to demential status, and to assess whether they correlates to Mini-Mental State Examination (MMSE) and Functional Assessment Staging (FAST) scores. Forty-three participants were included, of whom 12 with probable AD, 18 with MCI and 13 with no objective cognitive decline. Serum leptin and hsCRP levels were evaluated by immunoturbidimetric method, and IL-6 and TNF-α by ELISA. Higher TNF-α levels were found in individuals with FAST stages 1/2 and normal scores evaluated by MMSE. hsCRP levels were inversely correlated with FAST stages. No association with function or global cognition was observed for leptin and IL-6 levels. However, women presented higher leptin serum levels than men while lower leptin and IL-6 le...Continue Reading

Citations

Jul 14, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Gang DengChanghong Wang
Feb 9, 2021·Cytokine & Growth Factor Reviews·Leane Perim RodriguesJuliana Lott Carvalho
Mar 9, 2021·Frontiers in Neuroscience·Matthew G PontifexDavid Vauzour
May 11, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ayan HusseinGeorge W Huntley
Sep 28, 2021·Pharmacological Reports : PR·Frideriki PoutoglidouDimitrios Kouvelas
Jan 7, 2022·The European Journal of Neuroscience·Sara EkraminasabSina Rashedi

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