Leptin in bovine colostrum and milk

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
L Pinotti, Fabia Rosi

Abstract

We studied leptin content in bovine colostrum, milk and plasma during the first month of lactation, and investigated relationships between selected milk components and milk leptin in five multiparous dairy cows. Colostrum/milk yield and composition were measured on days 0, 10, 20, and 30 of lactation. Leptin was assayed using a multi-species leptin RIA kit. Leptin concentration was 56 % lower in mature milk (day 10) than colostrum (13.90 vs. 6.14 microg/l; p < 0.001), but remained steady over the twenty days afterwards. Daily secretion of leptin into mature milk was 28 % lower than into colostrum (173.2 microg/d vs. 220.0 microg/d; p = 0.09) notwithstanding an 80 % increase in production. Colostrum and milk leptin levels correlated with fat (0.90; p < 0.001) and choline phospholipid (0.76; p < 0.05). Plasma and milk leptin decreased during the first month, but remained higher in milk, and highest in colostrum. Thus, leptin is present in large quantities in colostrum, less so and more variably in untreated milk, and is likely to be decreased in skimmed milk. These findings have implications for the use of untreated milk and colostrum-based (functional) food products.

Citations

Mar 24, 2012·Animal : an International Journal of Animal Bioscience·A R G Wylie
Jun 23, 2009·Journal of Endocrinological Investigation·F RosiD Magistrelli
Oct 17, 2014·Journal of Animal Physiology and Animal Nutrition·V de BrunJ A Abecia
Apr 14, 2007·Journal of Animal Science·E L BergD H Keisler
Jan 23, 2021·Nutrients·Raymond John Playford, Michael James Weiser
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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