PMID: 9533757Apr 9, 1998Paper

Leptin in relation to prostate cancer and benign prostatic hyperplasia

International Journal of Cancer. Journal International Du Cancer
P LagiouChristos S Mantzoros

Abstract

The aim of our study was to determine whether leptin, a hormone implicated in both energy-balance and reproductive function, is involved in the etiology of prostate cancer or benign prostatic hyperplasia (BPH). We compared the serum leptin levels of 43 cases of incident prostate cancer, 41 patients with BPH, and 48 healthy controls, all recruited in Athens, Greece. Multiple logistic regression modeling was used, with adjustment for age, height, body mass index, education, estradiol, testosterone, dihydrotestosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin and insulin like growth factor 1. Odds ratios per 4 ng/ml increment of leptin were 0.70 [95% confidence interval (CI) (0.32,1.55)] for prostate cancer and 1.06 [95% CI (0.67,1.67)] for BPH. After adjustment for body mass index, serum leptin levels were not significantly correlated with levels of any of the other hormones under study. Leptin levels are unlikely to affect the risk of either prostate cancer or BPH substantially.

References

May 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·R Stege, K Carlström
Oct 1, 1995·The Journal of Clinical Investigation·D S WeigleJ L Kuijper
Jul 28, 1995·Science·M A PelleymounterF Collins
Sep 1, 1995·The Journal of Clinical Investigation·R C FrederichJ S Flier
Dec 1, 1994·Nature·T J Rink
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Feb 1, 1996·The New England Journal of Medicine·F Rohner-Jeanrenaud, B Jeanrenaud
Jul 18, 1996·Nature·R S AhimaJ S Flier
Aug 21, 1996·Journal of the National Cancer Institute·P H GannM J Stampfer
Jul 1, 1996·Endocrinology·I A BarashR A Steiner
Nov 1, 1996·Diabetes·J F CaroR V Considine
Nov 1, 1996·Cell·B M Spiegelman, J S Flier
Feb 1, 1997·The Journal of Clinical Investigation·R S AhimaJ S Flier
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·W H YuS M McCann
Jul 1, 1997·Cancer Causes & Control : CCC·L B SignorelloD Trichopoulos
Jan 1, 1997·British Journal of Cancer·C S MantzorosH O Adami
Dec 12, 1997·Oncology·P LagiouD Trichopoulos

❮ Previous
Next ❯

Citations

Oct 30, 2008·Asian Journal of Andrology·Jung Hoon KimMi Kyung Kim
Mar 26, 2014·Cancer Causes & Control : CCC·Gabriel Y LaiElizabeth A Platz
Feb 11, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gabriel Y LaiElizabeth A Platz
Mar 13, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ibrahim Serdar SerinKursad Unluhizarci
Sep 29, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·R RibeiroR Medeiros
May 15, 2007·Gastroenterology·Edward Giovannucci, Dominique Michaud
Aug 20, 2005·Journal of Cellular Physiology·Cecilia Garofalo, Eva Surmacz
May 4, 2006·International Journal of Clinical Practice·G CelikM Ozkan
Feb 6, 2007·International Journal of Cancer. Journal International Du Cancer·Tanja StocksPär Stattin
Mar 12, 2003·The Journal of Urology·Kenan SaglamSerdar Göktaş
Apr 20, 2004·The Journal of Surgical Research·Ponnandai SomasundarLinda C Vona-Davis
Sep 30, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Aneta CymbalukIzabella Rzepka-Górska
Jan 13, 2006·Biochemical and Biophysical Research Communications·Jeffrey D BubYoshiki Iwamoto
Oct 18, 2016·Critical Reviews in Food Science and Nutrition·Hiu Yee KwanZhi-Ling Yu
Dec 3, 2014·Metabolism: Clinical and Experimental·Fernando Miguel MendonçaCristina Abreu
Oct 19, 2001·Gynecologic Oncology·Y AbramovV Barak
Jul 12, 2002·The Prostate·Ann W HsingFrank Z Stanczyk
Feb 16, 2005·The Journal of Urology·Stephen J FreedlandAlan W Partin
Jun 29, 2006·The Cancer Journal·Wendy K Chung, Rudolph L Leibel
Mar 13, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S SöderbergB Ahrén
Nov 25, 2011·Nature Reviews. Cancer·Melin J KhandekarBruce M Spiegelman
Feb 15, 2001·The Prostate·S ChangM R Spitz
Sep 1, 2017·IUBMB Life·Xiaohui WangXiangyang Xie
Jul 29, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·R KaaksP Stattin
Feb 13, 2008·The American Journal of Clinical Nutrition·Ann W HsingStreamson Chua
Mar 12, 2004·The Journal of Surgical Research·Ponnandai SomasundarLinda Vona-Davis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Christos S MantzorosD W Cramer
Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
A K A SamadM A S Chapman
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Christine M FriedenreichLinda S Cook
© 2022 Meta ULC. All rights reserved