Abstract
Obesity is a recognized risk factor for endometrial cancer (EmCa) and other cancer types. Leptin levels are significantly increased in obese individuals. Leptin-induced signaling crosstalk [Notch, Interleukin-1 (IL-1) and leptin outcome, NILCO] has been associated with breast cancer progression. This complex signaling crosstalk affects cancer cell proliferation, migration, invasion, angiogenesis, apoptosis and chemoresistance. NILCO expression was previously detected in human EmCa. However, it is unknown whether leptin regulates NILCO and alters EmCa's response to chemotherapeutics. It is hypothesized that leptin induces NILCO and increases aggressiveness and chemoresistance in EmCa cells. To determine whether leptin induces NILCO molecules in EmCa affecting cell proliferation, aggressiveness and chemoresistance. Leptin's effects on the expression of NILCO molecules [mRNAs and proteins for Notch receptors (Notch1-4), ligands (JAG1 and DLL4) and downstream effectors (survivin, Hey2), and leptin (OB-R) and IL-1 (IL-1R tI) receptors] was examined in EmCa cells (type I: Ishikawa, and HEC-1A, and type II: An3Ca and KLE) using Real-time PCR and Western blot analysis, respectively. In addition, the effects of leptin on cell cycle, pro...Continue Reading
References
Nov 20, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S MargeticR A Hill
Aug 5, 2003·Endocrine·Ruben Rene Gonzalez, Paul C Leavis
Aug 12, 2008·Journal of Anatomy·Luigi CobellisAntonio De Luca
Sep 19, 2008·International Journal of Cancer. Journal International Du Cancer·Cecilia CarinoRuben R Gonzalez
Jul 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lily YangHui Mao
Jul 7, 2011·PloS One·Shanchun Guo, Ruben R Gonzalez-Perez
Aug 11, 2011·Development·Emma R AnderssonUrban Lendahl
Feb 22, 2012·Histopathology·Yuko MitsuhashiTanri Shiozawa
Jan 15, 2013·Medical Oncology·Violeta JonusieneJanina Didziapetriene
Feb 2, 2013·Clinical and Translational Medicine·Lissa Nurrul Abdullah, Edward Kai-Hua Chow
Apr 9, 2013·Molecular and Cellular Endocrinology·Gale Newman, Ruben Rene Gonzalez-Perez
Apr 9, 2013·Indian Journal of Endocrinology and Metabolism·Minglun TsaiAkio Inui
Oct 12, 2013·International Journal of Cancer. Journal International Du Cancer·Monica BattleRuben R Gonzalez-Perez
Jan 11, 2014·Gynecologic Oncology·Yvonne CollinsJohn H Farley
Apr 11, 2014·BMC Cancer·Laronna S ColbertRuben Rene Gonzalez-Perez
May 14, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Huei-Jean HuangChyong-Huey Lai
Mar 18, 2015·Hormone Molecular Biology and Clinical Investigation·Danielle Daley-BrownRuben R Gonzalez-Perez
Mar 29, 2016·World Journal of Methodology·Crystal C LipseyRuben R Gonzalez-Perez
Dec 22, 2016·Oncotarget·Adriana HarbuzariuRuben R Gonzalez-Perez
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 2, 2017·Archives of Medical Science : AMS·Luis Fernando Méndez-LópezMartha I Davila-Rodriguez
Feb 12, 2017·F1000Research·Arthur-Quan Tran, Paola Gehrig
Mar 2, 2017·BMJ : British Medical Journal·Maria KyrgiouKonstantinos K Tsilidis
Mar 2, 2017·World Journal of Clinical Oncology·Tia HarmonRuben R Gonzalez-Perez
Jul 1, 2017·Disease Markers·Danielle Daley-BrownRuben Rene Gonzalez-Perez
May 3, 2018·Oncotarget·Adriana Harbuzariu, Ruben Rene Gonzalez-Perez
Citations
May 31, 2020·International Journal of Molecular Sciences·Crystal C LipseyRuben R Gonzalez-Perez
Jun 13, 2020·Biomolecules·Salvatore PanzaSebastiano Andò
Oct 21, 2020·Cell Biology International·Qiong WuYubo Liu
Jan 20, 2021·Cellular and Molecular Life Sciences : CMLS·Aneesha Kulkarni, Laura W Bowers