Leptin induces TGF-beta synthesis through functional leptin receptor expressed by human peritoneal mesothelial cell.

Kidney International
J C K LeungK N Lai

Abstract

Marked increase in leptin concentration in spent peritoneal dialysate has been reported following continuous ambulatory peritoneal dialysis treatment. The present study was designed to determine whether functional leptin receptor is expressed by human peritoneal mesothelial cells and if so, the possible implication in dialysis. Expression of leptin receptors in cultured mesothelial cells and omental tissue was examined. The effect of leptin on the production of transforming growth factor-beta (TGF-beta) by mesothelial cells in the presence or absence of high glucose was determined using in vitro culture model of human peritoneal mesothelial cells and adipocytes. The signaling mechanism involved in leptin-induced TGF-beta synthesis by mesothelial cells was studied. Both mRNA and protein of the full-length leptin receptor are constitutively expressed in mesothelial cells. The leptin receptor expression in mesothelial cells was upregulated by glucose but not leptin. In adipocytes, glucose increased the mRNA expression and synthesis of leptin. The Janus kinase-signal transducers and activation (JAK-STAT) signal transduction pathway in mesothelial cells was activated by either exogenous or adipocytes-derived leptin. Exogenous leptin...Continue Reading

References

Jul 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J RubinD Collins
Nov 16, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Y TsujimotoH Morii
Apr 15, 2000·Nature·J M Friedman
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Takafumi ItoMichio Yamakido
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Cora WeigertErwin D Schleicher
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·Kar Neng LaiJoseph C Leung
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·G FrühbeckM A Burrell
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Peter J MargettsJack Gauldie
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H Zarkesh-EsfahaniR J Ross
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gunter WolfFuad N Ziyadeh
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Peter J MargettsJack Gauldie
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Luis CarrerasMarta Carrera
Nov 1, 2002·Current Opinion in Rheumatology·Hironobu Ihn
Feb 26, 2003·The Journal of Biological Chemistry·Edward YangJames E Darnell
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Masakazu HanedaRyuichi Kikkawa
May 8, 2003·The Journal of Biological Chemistry·Stefania CatalanoSebastiano Andò
Jan 30, 2004·Recent Progress in Hormone Research·Martin G Myers
May 26, 2004·Physiology & Behavior·Rexford S Ahima, Suzette Y Osei
Oct 20, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Zheng-Juan LiuTakehiko Ohzeki
Apr 9, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joseph C K LeungKar Neng Lai
Apr 9, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel TetaKevin Harris
Jun 11, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Caroline M Pond

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Citations

Mar 26, 2013·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Shigehisa AokiShuji Toda
Sep 23, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joseph C K LeungKar Neng Lai
Jan 31, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joseph C K LeungKar Neng Lai
Nov 3, 2011·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Kar Neng LaiSydney C W Tang
Jan 1, 2014·TheScientificWorldJournal·Maria Roszkowska-Blaim, Piotr Skrzypczyk
May 11, 2010·Mediators of Inflammation·Kar Neng Lai, Joseph C K Leung
Apr 21, 2009·Gastroenterology·Jianhua WangJacob George
Jun 28, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rao Gurugubelli Krishna, B Vishnu Bhat
Jun 10, 2016·American Journal of Physiology. Cell Physiology·Soumyadip SahuPriya Raman
Jun 10, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Pilar SandovalManuel López-Cabrera
May 5, 2016·Journal of the American Heart Association·Danny Ben-ZviJacob Schneiderman
Mar 3, 2007·Expert Review of Molecular Diagnostics·Ancha BaranovaZobair M Younossi
May 18, 2012·American Journal of Physiology. Cell Physiology·Ronaldo J ChavezPriya Raman
May 31, 2013·Acta Histochemica Et Cytochemica·Masayuki NakazawaShigeru Kohno
Aug 10, 2007·American Journal of Physiology. Renal Physiology·Philipp KümpersMario Schiffer
Apr 8, 2021·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Yingfeng ShiNa Liu
Jun 3, 2021·International Journal of Molecular Sciences·Priya Raman, Saugat Khanal
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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