Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF

Proceedings of the National Academy of Sciences of the United States of America
R CaoY Cao

Abstract

Most endocrine hormones are produced in tissues and organs with permeable microvessels that may provide an excess of hormones to be transported by the blood circulation to the distal target organ. Here, we investigate whether leptin, an endocrine hormone, induces the formation of vascular fenestrations and permeability, and we characterize its angiogenic property in the presence of other angiogenic factors. We provide evidence that leptin-induced new blood vessels are fenestrated. Under physiological conditions, capillary fenestrations are found in the leptin-producing adipose tissue in lean mice. In contrast, no vascular fenestrations were detected in the adipose tissue of leptin-deficient ob/ob mice. Thus, leptin plays a critical role in the maintenance and regulation of vascular fenestrations in the adipose tissue. Leptin induces a rapid vascular permeability response when administrated intradermally. Further, leptin synergistically stimulates angiogenesis with fibroblast growth factor (FGF)-2 and vascular endothelial growth factor (VEGF), the two most potent and commonly expressed angiogenic factors. These findings demonstrate that leptin has another new function-the increase of vascular permeability.

References

Sep 1, 1991·The Journal of Cell Biology·Y M FuW Casscells
Sep 1, 1995·The Journal of Clinical Investigation·R C FrederichJ S Flier
May 1, 1994·Immunopharmacology and Immunotoxicology·D M KelleyS M Dubinett
Feb 15, 1996·Nature·G H LeeJ M Friedman
Jan 24, 1998·The Journal of Biological Chemistry·C BjørbaekJ S Flier
Mar 21, 1998·The Journal of Cell Biology·S EsserW Risau
Sep 11, 1998·Science·M R Sierra-HonigmannJ R Flores-Riveros
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Nov 14, 1998·Circulation Research·A BouloumiéR Busse
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y CaoK Alitalo
Apr 8, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P TrayhurnD V Rayner
Apr 14, 1999·Nature·Y Cao, R Cao
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·R CaoY Cao
Nov 26, 1999·The Journal of Investigative Dermatology·J L ArbiserJ A Majzoub
Dec 2, 1999·Nature Medicine·N Ferrara, K Alitalo
Dec 14, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R CaoY Cao
Apr 15, 2000·Nature·J M Friedman

❮ Previous
Next ❯

Citations

Jul 31, 2008·Archives of Gynecology and Obstetrics·Tayfun GungorLeyla Mollamahmutoglu
Aug 11, 2010·Clinical & Experimental Metastasis·Lin Yan, Lana C DeMars
Nov 12, 2013·Journal of Mammary Gland Biology and Neoplasia·Neeraj K Saxena, Dipali Sharma
Mar 17, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Edgard Engelman, Cécile Maeyens
Jul 22, 2005·Current Diabetes Reports·Kamal Rahmouni, William G Haynes
Nov 27, 2008·Genes & Nutrition·Lukasz WatorAldona Dembinska-Kiec
Mar 12, 2004·The Journal of Surgical Research·Ponnandai SomasundarLinda Vona-Davis
Jun 16, 2005·Molecular and Cellular Endocrinology·Caitlin S WyrwollBrendan J Waddell
Jan 22, 2003·Animal Reproduction Science·S Schäfer-Somi
Jul 20, 2002·Current Opinion in Pharmacology·Srinivasan Madhusudan, Adrian L Harris
Apr 13, 2005·Reproductive Biomedicine Online·A CerveroC Simón
Apr 1, 2009·Animal : an International Journal of Animal Bioscience·Z E MadejaM Switonski
Jan 9, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Md Nazir HossenHideyoshi Harashima
Nov 16, 2011·Nature Reviews. Endocrinology·Sebastiano Andò, Stefania Catalano
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yuan XueYihai Cao
Sep 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eduardo A SilvaDavid J Mooney
Oct 26, 2005·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Orhan AydemirA Sahap Kükner
May 1, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Dror MichaelsonM R Smith
Jun 29, 2006·The Cancer Journal·Wendy K Chung, Rudolph L Leibel
Aug 31, 2011·Anti-cancer Drugs·Ingrid M E DesarWinette T A van der Graaf
Apr 24, 2012·Clinical and Experimental Pharmacology & Physiology·Matthias Van HulH Roger Lijnen
Jan 7, 2009·Journal of Biomedical Optics·Dodanim Talavera-AdameDaniel L Farkas
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Can PangJianping Ye
Nov 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mary Jo Mulligan-Kehoe
Jan 9, 2009·American Journal of Physiology. Renal Physiology·Simon C Satchell, Filip Braet
Jan 21, 2012·Neurology Research International·Johnathan E LawrenceRobert J Winn
Aug 16, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Adana A LlanosPeter G Shields
Apr 2, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Hamdi ErMuhittin Yürekli
Mar 1, 2013·Thrombosis and Haemostasis·Ilse ScroyenH Roger Lijnen
Sep 6, 2007·The Journal of Clinical Investigation·Yihai Cao
Nov 3, 2010·Respiratory Research·Foteini MalliZoe Daniil
Nov 23, 2005·BMC Gastroenterology·Alper HaciogluGungor Kanbak
Apr 7, 2009·Lipids in Health and Disease·Adriana BalwierzAldona Dembinska-Kiec
Apr 22, 2010·Italian Journal of Pediatrics·Nagla T El-Melegy, Nagwa A Mohamed
Sep 15, 2009·European Journal of Medical Research·Lori Sweeney, Norbert F Voelkel
Mar 18, 2010·The Journal of Veterinary Medical Science·Tomoya YamadaNaoto Nakanishi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.