PMID: 9451467Feb 6, 1998Paper

Leptin inhibition of insulin secretion from isolated human islets

Acta Diabetologica
H C FehmannB Göke

Abstract

Leptin is a hormone produced and secreted from the adipose tissue. Its physiological actions include the regulation of satiety, food intake and energy balance. The production of leptin is increased by high insulin levels. Here, we demonstrate that leptin acts as an inhibitor of glucose-induced (20 mM) insulin secretion from isolated human islets. No effect was observed in the presence of lower glucose levels (2.8 and 10 mM glucose). The pancreatic beta-cell might represent a target of a direct physiological action of leptin. We suggest the presence of an "adipo-insular axis" in which leptin mediates negative feedback from the adipose tissue to the endocrine pancreas.

Citations

Mar 31, 2011·Journal of Clinical Research in Pediatric Endocrinology·Kristin S OndrakJoanne S Harrell
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·J SeufertJ F Habener
Feb 3, 2000·Critical Reviews in Clinical Laboratory Sciences·J Himms-Hagen
Oct 10, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G-C ChenJ-K Ye
Dec 17, 2008·Journal of Bodywork and Movement Therapies·Judith DeLany
Aug 16, 2016·Endocrinology and Metabolism Clinics of North America·Georgios A TriantafyllouChristos S Mantzoros
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Jan 4, 2001·The Journal of Nutrition·S Kim, N Moustaid-Moussa

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