PMID: 18404969Apr 15, 2008Paper

Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers

Journal of Pediatric Endocrinology & Metabolism : JPEM
M Martha Vela-HuertaJavier Hernnández

Abstract

It has been suggested that hyperleptinemia could be caused by hyperinsulinemia in infants of diabetic mothers (IDMs). To compare leptin, insulin, and glucose levels in large-for-gestational-age (LGA) and appropriate-for-gestational-age (AGA) infants. A cross-sectional study was conducted in IDMs, infants of non-diabetic mothers (INDM) and AGA infants. Seventy-seven newborns were studied (11 IDM, 16 INDM, and 50 AGA infants). Leptin levels were significantly higher in LGA infants than in the AGA group and a trend for higher levels in IDM than NIDM was observed. Insulin levels and insulin resistance were significantly higher in IDMs. Glucose levels were lower in both groups of LGA infants. We found insulin resistance, hyperinsulinism and hyperleptinemia in IDMs, and the trend of higher leptin levels in IDMs than INDMs shows that leptin could be related to insulin resistance in these infants.

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Citations

Aug 18, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yongli ChuXueqiang Jiang
Apr 19, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yong ZhangYing-xiong Wang
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Sep 21, 2011·Pediatrics·Yoram BentalUNKNOWN Collaboration With the Israel Neonatal Network

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