Leptin is associated with disease activity but not with anthropometric indices in rheumatoid arthritis patients

Archives of Medical Science : AMS
Amela DerviševićAlmira Hadžović-Dzuvo

Abstract

Leptin is a cytokine-like hormone which has a complex role in inflammation. However, the importance of leptin in the pathogenesis of rheumatoid arthritis (RA) is far from being fully elucidated. The aim of the study was to determine serum leptin levels in RA patients and to evaluate whether there is an association between disease activity, anthropometric indices and leptin levels. This hypothesis-generating study included 55 RA patients and 25 matched healthy subjects. The serum leptin concentration was determined by enzyme-linked immunosorbent assay (ELISA). Median serum leptin level in RA patients of 27.4 ng/ml (14.5-54.9 ng/ml) was statistically significantly higher (p = 0.03) compared with the median leptin value of 16.3 ng/ml (9.6-38.8 ng/ml) determined in healthy controls. The serum leptin level in the high disease activity group was significantly higher (p < 0.0005) than that in the low disease activity group and in healthy controls. A significant difference (p = 0.001) in serum leptin level was also found when the high disease activity group was compared with the moderate disease activity group. In the RA group a statistically significant positive correlation (rho = 0.390; p = 0.003) was observed between serum leptin le...Continue Reading

Citations

Oct 22, 2020·BioMed Research International·Sha-Sha TaoHai-Feng Pan
Feb 27, 2021·Archives of Medical Research·Ali TaylanBahar Engin
Jul 27, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Gashaw DessieMeseret Derbew Molla
May 27, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Aulikki KononoffOili Kaipiainen-Seppänen

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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