Leptin levels and lipoprotein profiles in patients with cholelithiasis

The Journal of International Medical Research
Serdar SaraçNecati Yenice

Abstract

To determine the relationships between serum leptin and levels of lipoprotein(a) [Lp(a)], apolipoprotein A-1 (ApoA-1) and apolipoprotein B (ApoB) in patients with cholelithiasis. Patients with ultrasound-confirmed cholelithiasis and controls frequency-matched for age, sex, body mass index, fasting blood glucose and haemoglobin A1c levels were recruited. Fasting blood samples from all study participants were assayed for glucose, haemoglobin A1c, total cholesterol, high density lipoprotein-cholesterol (HDL-C) and triglyceride. Serum Lp(a), ApoA-1 and ApoB levels were measured using nephelometric assays; serum leptin was measured using an enzyme-linked immunosorbent assay. A total of 90 patients with cholelithiasis and 50 controls were included in the study. Serum levels of leptin, Lp(a), total cholesterol, triglyceride and ApoB were significantly increased, and levels of ApoA-1 and HDL-C were significantly decreased, in patients with cholelithiasis compared with controls. Serum leptin in patients with cholelithiasis were significantly positively correlated with Lp(a) and ApoB and negatively correlated with ApoA-1. Patients with cholelithiasis have higher leptin levels and an altered lipoprotein profile compared with controls, wit...Continue Reading

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Citations

Oct 25, 2016·Acta histochemica·Sungin LeeWan Hee Kim
Dec 30, 2016·Journal of Veterinary Internal Medicine·S LeeW H Kim
Mar 21, 2020·Lipids in Health and Disease·Jiwen WangHoubao Liu
Jul 1, 2020·Terapevticheskiĭ arkhiv·N A CherkashchenkoT S Krolevets
May 5, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Haifeng ZhuLinsong Feng

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS®
SPSS

Related Concepts

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Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.