Leptin links with plasminogen activator inhibitor-1 in human obesity: the SABPA study

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Chiné PieterseAletta E Schutte

Abstract

The relationship between obesity and the development of cardiovascular disease is well established. However, the underlying mechanisms contributing to vascular disease and increased cardiovascular risk in the obese remain largely unexplored. Since leptin exerts direct vascular effects, we investigated leptin and the relationship thereof with circulating markers of vascular damage, namely plasminogen activator inhibitor-1 antigen (PAI-1(ag)), von Willebrand factor antigen (vWF(ag)) and urinary albumin-to-creatinine ratio (ACR). The study included a bi-ethnic population of 409 African and Caucasian teachers who were stratified into lean (<0.5) and obese (⩾0.5) groups according to waist-to-height ratio. We obtained ambulatory blood pressure measurements and determined serum leptin levels, PAI-1(ag), vWF(ag) and ACR, as markers of vascular damage. The obese group had higher leptin (P<0.001) and PAI-1(ag) (P<0.001) levels and a tendency existed for higher vWF(ag) (P=0.068). ACR did not differ between the two groups (P=0.21). In single regression analyses positive associations existed between leptin and all markers of vascular damage (all P<0.001) only in the obese group. After adjusting for covariates and confounders in multiple reg...Continue Reading

References

Feb 15, 1989·Thrombosis Research·B E PottingerJ D Pearson
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T SkurkH Hauner
Nov 25, 2003·Journal of Thrombosis and Haemostasis : JTH·M T GuagnanoG Davì
Apr 27, 2005·Journal of Molecular and Cellular Cardiology·Ruth Miskin, Rene Abramovitz
May 19, 2006·Journal of Thrombosis and Haemostasis : JTH·U M Vischer
Oct 14, 2006·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M-T van der Merwe, M S Pepper
Jun 21, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Muriel MeiringMareli Kelderman
Dec 26, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Ikechi G OkpechiBrian L Rayner
Aug 12, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Mykhaylo KordaTadeusz Malinski
Jan 7, 2010·Biochemical and Biophysical Research Communications·Prachi SinghVirend K Somers
Mar 30, 2010·The Journal of Biological Chemistry·John E HallDavid E Stec
Aug 14, 2010·American Journal of Hypertension·Theodore A Kotchen
Dec 15, 2010·Atherosclerosis·Jerome L AbramsonNancy V Murrah
Jan 10, 2012·Nutrition Reviews·Barry M PopkinShu Wen Ng
Mar 1, 2012·British Journal of Haematology·Takayuki IwakiKazuo Umemura
May 10, 2012·Journal of Thrombosis and Haemostasis : JTH·J E van LoonM P M de Maat
Feb 15, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Gabriela A EppelRoger G Evans
May 10, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jennifer N CooperKim Sutton-Tyrrell
May 22, 2013·Current Pharmaceutical Design·Gregory A PayneJarrod D Knudson
Oct 12, 2013·PloS One·Katherine T MillsJing Chen
Feb 11, 2014·Journal of Hypertension·Chiné PieterseAletta E Schutte

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