Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1

Frontiers in Immunology
Glaucia Souza-AlmeidaClarissa M Maya-Monteiro

Abstract

Leptin directly activates macrophages and lymphocytes, but the role of leptin in neutrophil activation and migration is still controversial. Here, we investigate the in vivo mechanisms of neutrophil migration induced by leptin. The intraperitoneal injection of leptin (1 mg/kg) induces a time- and concentration-dependent neutrophil influx. We did not observe the enhancement of lipid bodies/droplets in neutrophils, after leptin treatment, as we had observed previously in peritoneal macrophages. The participation of leukotriene B4 (LTB4) in neutrophil recruitment triggered by leptin was investigated using different strategies. Leptin-induced neutrophil recruitment occurs both in the absence of 5-lipoxygenase activity in 5-lipoxygenase (5-LO)-/- mice and after the administration of either 5-LO inhibitor (Zileuton) or the LTB4 receptor antagonist (U-75302). Moreover, no direct induction of LTB4 by leptin could be observed. Neutrophil influx could not be prevented by the mammalian target of rapamycin (mTOR) inhibitor, rapamycin, contrasting with the leptin-induced signaling for lipid body formation in macrophage that is mTOR-dependent. Leptin administration led to tumor necrosis factor-alpha (TNFα) production by the peritoneal cells ...Continue Reading

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Citations

Jul 3, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Torsten SchröderYves Laumonnier
Jan 11, 2020·Frontiers in Endocrinology·Lohanna PalhinhaClarissa Menezes Maya-Monteiro
Aug 9, 2020·Immunopharmacology and Immunotoxicology·Ramachandran Vidhya, Carani Venkatraman Anuradha
May 16, 2019·Journal of Leukocyte Biology·Lauar MonteiroPedro Manoel M Moraes-Vieira
Nov 11, 2019·Clinical Rheumatology·Qihang YuanJing Wei
Jul 15, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ayoub SaeidiHassane Zouhal
Oct 19, 2020·Journal of Leukocyte Biology·Glaucia Souza-AlmeidaClarissa Menezes Maya-Monteiro
Oct 30, 2020·Frontiers in Endocrinology·Natália R T AmorimChristianne Bandeira-Melo
Jan 20, 2021·Cellular and Molecular Life Sciences : CMLS·Aneesha Kulkarni, Laura W Bowers
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Fernanda B AndradeEugenio D Hottz
Jul 25, 2021·International Journal of Molecular Sciences·Iason ThomasAthanasia Mouzaki

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Methods Mentioned

BETA
lavage
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Cell F Imaging

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