Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk.

The Journal of Clinical Investigation
Rachel J PerryGerald I Shulman

Abstract

Meal ingestion increases body temperature in multiple species, an effect that is blunted by obesity. However, the mechanisms responsible for these phenomena remain incompletely understood. Here we show that refeeding increases plasma leptin concentrations approximately 8-fold in 48-hour-fasted lean rats, and this normalization of plasma leptin concentrations stimulates adrenomedullary catecholamine secretion. Increased adrenal medulla-derived plasma catecholamines were necessary and sufficient to increase body temperature postprandially, a process that required both fatty acids generated from adipose tissue lipolysis and β-adrenergic activation of brown adipose tissue (BAT). Diet-induced obese rats, which remained relatively hyperleptinemic while fasting, did not exhibit fasting-induced reductions in temperature. To examine the impact of feeding-induced increases in body temperature on energy balance, we compared rats fed chronically by either 2 carbohydrate-rich boluses daily or a continuous isocaloric intragastric infusion. Bolus feeding increased body temperature and reduced weight gain compared with continuous feeding, an effect abrogated by treatment with atenolol. In summary, these data demonstrate that leptin stimulat...Continue Reading

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Citations

Jun 27, 2020·International Journal of Molecular Sciences·Shih-Yi LinChun-Jung Chen
Jul 1, 2020·Journal of Nutritional Science·Paul Trayhurn, Jonathan R S Arch
Sep 2, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Andin Fosam, Rachel J Perry
Nov 24, 2020·American Journal of Physiology. Endocrinology and Metabolism·Rahel Catherina LoeligerMatthias Johannes Betz
Dec 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xiruo LiGerald I Shulman
Nov 13, 2020·The Journal of Clinical Endocrinology and Metabolism·Milena Monfort-PiresLicio A Velloso
Jan 19, 2021·American Journal of Physiology. Endocrinology and Metabolism·Rafael C GasparVitor R Muñoz
Apr 13, 2021·American Journal of Physiology. Endocrinology and Metabolism·Kitt Falk PetersenGerald I Shulman
Jun 5, 2021·Hormones and Behavior·Jin PengXiaohui Wang
Jun 24, 2021·Physiology·Heike MünzbergJi Suk Chang

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Methods Mentioned

BETA
ELISA

Software Mentioned

BDAS Basic
GraphPad Prism

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