Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus

Endocrinology
Gábor LégrádiRonald M Lechan

Abstract

Prolonged fasting is associated with a number of changes in the thyroid axis manifested by low serum T3 and T4 levels and, paradoxically, low or normal TSH. This response is, at least partly, caused by suppression of proTRH gene expression in neurons of the hypothalamic paraventricular nucleus (PVN) and reduced hypothalamic TRH release. Because the fall in thyroid hormone levels can be blunted in mice by the systemic administration of leptin, we raised the possibility that leptin may have an important role in the neuroendocrine regulation of the thyroid axis, through effects on hypophysiotropic neurons producing proTRH. Adult male, Sprague-Dawley rats were either fed normally, fasted for 3 days, or fasted and administered leptin at a dose of 0.5 microg/gm BW i.p. every 6 h. Fasted animals showed significant reduction in plasma total and free T4 and T3 levels compared with controls, that were restored toward normal by the administration of leptin. Percent free T4, but not percent free T3, increased during fasting, further suggesting a reduction in plasma transthyretin levels that did not return to fed levels after leptin administration. By semiquantitative analysis of in situ hybridization autoradiograms, proTRH messenger RNA in...Continue Reading

References

Sep 1, 1978·Metabolism: Clinical and Experimental·A R HarrisL E Barverman
Mar 15, 1979·The New England Journal of Medicine·D F GardnerR D Utiger
Jul 1, 1991·The British Journal of Nutrition·C J WoodwardE M Whitaker
Jul 1, 1990·Acta Endocrinologica·C H EmersonS L Fang
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·T van der PollH P Sauerwein
Dec 1, 1985·Journal of Endocrinological Investigation·S AmrB D Weintraub
Jul 1, 1986·The Journal of Clinical Endocrinology and Metabolism·G A Brent, J M Hershman
Jan 1, 1986·Neuroendocrinology·K IshikawaM Suzuki
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K J KollerR T Zoeller
Oct 1, 1988·Acta Endocrinologica·J N HuguesA Enjalbert
Apr 1, 1985·The Journal of Clinical Investigation·W B KinlawJ H Oppenheimer
Jan 1, 1982·Neuroendocrinology·L Krulich
Sep 1, 1995·The Journal of Clinical Investigation·R C FrederichJ S Flier

❮ Previous
Next ❯

Citations

Jan 1, 2011·Nutrition & Diabetes·N J PoritsanosT M Mizuno
Apr 10, 1999·Clinical Endocrinology·C S Mantzoros, S J Moschos
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·J K ElmquistC B Saper
Dec 11, 2008·Thyroid : Official Journal of the American Thyroid Association·Jacqueline Jonklaas, Steven J Soldin
Sep 24, 2002·Archives of Disease in Childhood·T Reinehr, W Andler
Jul 28, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christos S MantzorosAnastasia Koniaris
Jan 3, 2001·The Journal of Clinical Investigation·M HarrisA N Hollenberg
May 3, 2003·The Journal of Clinical Investigation·Jean L ChanChristos S Mantzoros
Dec 3, 2005·The Journal of Clinical Investigation·Michael RosenbaumRudolph L Leibel
Oct 4, 2006·The Journal of Clinical Investigation·Antonio C Bianco, Brian W Kim
Jun 21, 2011·Journal of Thyroid Research·Anjali AminKevin G Murphy
Jul 11, 2014·Journal of Chemical Neuroanatomy·M M H van SwietenG van der Plasse
Dec 29, 2011·Endocrinology·Jin Kwon JeongSabrina Diano
Feb 7, 2013·American Journal of Physiology. Endocrinology and Metabolism·Miles E MatsenGregory J Morton
Sep 26, 2013·Journal of Nutritional Science and Vitaminology·Wataru MizunoyaYoshihide Ikeuchi
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·S S Yen
Feb 7, 2004·Archives of Gerontology and Geriatrics·D MaugeriP Panebianco
Jun 12, 1999·Thyroid : Official Journal of the American Thyroid Association·M A SyedL A Burmeister
Nov 7, 2009·Asian Journal of Surgery·Melih AkinciAbdullah Cetin
Jul 6, 2010·Frontiers in Neuroendocrinology·Tina A DardenoChristos S Mantzoros
Oct 14, 2009·Molecular and Cellular Endocrinology·A Sainsbury, L Zhang
Nov 6, 2009·Physiology & Behavior·Carmen Ruth GonzálezCarlos Diéguez
Nov 26, 2009·Physiology & Behavior·Ka Yan NgTandra R Chakraborty
Sep 5, 2009·Trends in Biochemical Sciences·Francisca LagoOreste Gualillo
Jun 23, 2009·Molecular and Cellular Endocrinology·Thomas Reinehr
Nov 17, 2007·Cytokine·Pedro Iglesias, Juan J Díez
Oct 2, 2007·Life Sciences·Elaine de OliveiraPatrícia Cristina Lisboa
Mar 14, 2007·Life Sciences·Magna Cottini Fonseca PassosEgberto Gaspar de Moura
Jul 20, 2005·Acta Physiologica Scandinavica·E SilvestriF Goglia
Feb 14, 2004·Journal of Neuroendocrinology·M J CunninghamR A Steiner
Nov 18, 2008·Journal of Animal Physiology and Animal Nutrition·S Van WeyenbergG P J Janssens

❮ Previous
Next ❯

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