Leptin Promotes Prostate Cancer Proliferation and Migration by Stimulating STAT3 Pathway.

Nutrition and Cancer
Amal GorrabAsma Gati

Abstract

To better understand the link between obesity and prostate cancer (PC) aggressiveness, we investigate the role of leptin, an obesity associated adipokine, and its receptor (Ob-R) in PC cells migration. The migration assay (Wound-healing) was used to study the leptin impact on DU-145 and PC3 cells lines. STAT3 activation was performed by Western Blot. E-cadherin expression was studied using fluorescence microscopy and Ob-R expression in PC and benign prostatic Hyperplasia (BPH) biopsies was assessed by RT-PCR. In this study we demonstrate that high dose of leptin promotes PC cells migration and EMT transition via the stimulation of STAT3 pathway. In addition, we report that although Ob-R mRNA is expressed by ADK and BPH resections biopsies, significant higher levels were observed for ADK patients. Finally, we found a positive association between Ob-R mRNA expression and worse PC prognosis. A better understanding of the molecular processes of leptin signaling is crucial for identifying appropriate approaches for treatment of obesity-related PC patients.

References

Jan 24, 1998·The Journal of Biological Chemistry·C BjørbaekJ S Flier
May 22, 2002·Cellular Signalling·Gary Sweeney
Dec 13, 2005·The Biochemical Journal·Gema Frühbeck
Oct 17, 2007·Annual Review of Physiology·Martin G MyersHeike Münzberg
Feb 5, 2008·Biochemical and Biophysical Research Communications·Haiping JiangShaoqing Chen
Mar 6, 2008·Neoplasia : an International Journal for Oncology Research·Hua XiongJing-Yuan Fang
May 9, 2008·Current Infectious Disease Reports·David A Bobak
Oct 30, 2008·Asian Journal of Andrology·Jung Hoon KimMi Kyung Kim
Oct 8, 2009·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hee Sung Kim
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Feb 13, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J M HowardJ V Reynolds
Mar 29, 2011·Molecular Interventions·Paul A Johnston, Jennifer R Grandis
Dec 12, 2012·European Urology·Emma H AllottStephen J Freedland
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Sep 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shahab UddinKhawla S Al-Kuraya
Sep 30, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Adriana C VidalStephen J Freedland
Sep 30, 2014·International Journal of Cancer. Journal International Du Cancer·Henrik MøllerAnne Tjønneland
Oct 30, 2014·Acta Cirúrgica Brasileira·Clarice F OsórioFrancisco J B Sampaio
Apr 5, 2015·Cancer Research·Chao-Ching ChangChun-Ju Chang
Nov 11, 2015·Endocrine-related Cancer·Jeong Won ParkSheue-yann Cheng
Jan 13, 2016·Nature Communications·Victor LaurentCatherine Muller
Apr 16, 2016·International Journal of Oncology·Kuangfa LiTingmei Chen
Sep 30, 2016·Cancer Epidemiology·Mónica S SierraDavid Forman
Apr 18, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hongzhi DuLi Sun
Jun 5, 2017·The Medical Clinics of North America·Michael J Barry, Leigh H Simmons
Aug 5, 2017·Cellular Oncology (Dordrecht)·Yunxiu HuangBing Li
Apr 11, 2018·Frontiers in Endocrinology·Stefanie FruhwürthKevin Jon Williams
May 22, 2018·International Journal of Biological Macromolecules·Nazanin FathiSimin Sharifi
Jan 13, 2019·Cancers·Sebastiano AndòStefania Catalano
Mar 17, 2019·Cellular Oncology (Dordrecht)·Ahmad GhasemiSeyed Isaac Hashemy

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Citations

Dec 19, 2020·Biomolecules·Monserrat Olea-FloresNapoleón Navarro-Tito
Feb 19, 2021·Expert Opinion on Investigational Drugs·Matteo SantoniNicola Battelli
Apr 4, 2021·International Journal of Molecular Sciences·Tsung-Chieh Lin, Michael Hsiao
Jul 3, 2021·Biomolecules·Carlos Jiménez-CorteganaVíctor Sánchez-Margalet

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