Leptin receptor gene variation and obesity: lack of association in a white British male population

Human Molecular Genetics
T GotodaT J Aitman

Abstract

Leptin, a hormone secreted by adipocytes, plays a pivotal role in the control of body weight. Rodents with mutations in the leptin receptor gene develop morbid obesity. It is possible, therefore, that leptin receptor gene mutations contribute to human obesity. To test this possibility, we determined the entire coding sequence of the human leptin receptor cDNA from peripheral blood lymphocytes of 22 morbidly obese patients with body-mass index (BMI) between 35.1 and 60.9 kg/m2. We identified five common DNA sequence variants distributed throughout the coding sequence at codons 109, 223, 343, 656 and 1019, one rare silent mutation at codon 986 and one novel alternatively spliced form of transcript. None of the five common variants, including the three that predict amino acid changes, are null mutations causing morbid obesity, because homozygotes for the variant sequences were also found in lean subjects. Furthermore, the frequency of each variant allele and the distribution of genotypes and haplotypes were similar in 190 obese (BMI >28 kg/m2) and 132 lean (BMI <22 kg/m2) white British males selected from a population-based epidemiological survey. In these subjects, there was no evidence for a significant effect of the common vari...Continue Reading

References

Jun 1, 1991·The American Journal of Clinical Nutrition·W C KnowlerP H Bennett
May 24, 1990·The New England Journal of Medicine·A J StunkardG E McClearn
Jul 28, 1995·Science·M A PelleymounterF Collins
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Dec 29, 1995·Cell·L A TartagliaR I Tepper
Mar 27, 1996·Biochemical and Biophysical Research Communications·R V ConsidineJ F Caro
Feb 15, 1996·Nature·G H LeeJ M Friedman
May 1, 1996·Nature Genetics·M S PhillipsJ F Hess
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·N GhilardiR C Skoda

❮ Previous
Next ❯

Citations

Dec 13, 2002·Fertility and Sterility·Cemal Tamer ErelBulent Baysal
Jun 15, 1999·Trends in Pharmacological Sciences·A D Strosberg, T Issad
Mar 1, 2003·Regulatory Peptides·M Friedman-EinatA D Strosberg
Oct 30, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M den HoedK R Westerterp
Jan 25, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G M van der VleutenJ de Graaf
Jul 11, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R H PodolskyH Snieder
May 31, 2001·European Journal of Clinical Investigation·O MammèsF Fumeron
Jul 8, 1999·Journal of Internal Medicine·S M Echwald
Aug 9, 2003·The New England Journal of Medicine·Takanari Gotoda
Oct 30, 2001·The Proceedings of the Nutrition Society·G Frühbeck
Jun 23, 2000·Clinical Obstetrics and Gynecology·P Dar, S J Gross
Aug 22, 2006·Diabetes, Obesity & Metabolism·T GohdaY Tomino
Apr 2, 1999·Acta Paediatrica. Supplement·K Clément
Feb 12, 2009·Infectious Agents and Cancer·Camille C RaginEmanuela Taioli
Oct 10, 2014·Journal of Human Genetics·Željka TomasNina Smolej Narančić
Oct 16, 2008·Journal of Cancer Research and Clinical Oncology·Christos YapijakisEleftherios Vairaktaris
Jun 17, 2015·Leukemia & Lymphoma·Shahab Uddin, Ramzi M Mohammad
Feb 5, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Aleksandra SzczepankiewiczAnna Popiel
Nov 4, 2000·Expert Opinion on Investigational Drugs·J ProiettoA W Thorburn
Jan 9, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·F AydinA Y Turanli
Jan 21, 2016·Cellular and Molecular Life Sciences : CMLS·Obin KwonMin-Seon Kim
Mar 23, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S Ben AliN Kaabachi
May 12, 2009·Archives of Medical Research·Samir Ben AliNaziha Kaabachi
Apr 29, 2008·Diabetes Research and Clinical Practice·Yanchun QuLi Wang
Jun 30, 2004·Diabetes & Metabolism·R CancelloK Clément
Jan 5, 2008·International Journal of Dermatology·Nurten KaraAhmet Yasar Turanli
Nov 11, 2008·Obesity·George StratigopoulosRudolph L Leibel
May 8, 2004·Metabolism: Clinical and Experimental·Akiko Takahashi-YasunoKazuwa Nakao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.