Leptin receptor immunoreactivity is present in ascending serotonergic and catecholaminergic neurons of the rat

Neuroendocrinology
A Hay-SchmidtP J Larsen

Abstract

Using double-labelling immunohistochemistry we have studied the localisation of leptin receptor proteins including both long and short forms and their possible presence in serotonergic (5-HT) and catecholaminergic neurons in the rat brain. Leptin receptor immunoreactivity was found to be widely distributed in the central nervous system including cortical areas, amygdala, several hypothalamic and thalamic nuclei, the raphe system, pontine nuclei, locus coeruleus, parabrachial nucleus, tractus solitarus and the medullary reticular formation. Serotonergic cell groups were identified by 5-HT immunocytochemistry and classified according to standard nomenclature. High degrees of co-existence of leptin receptor immunoreactivity with serotonin in the raphe system were observed in B1, B5, B6, B7, B8 and B9. In B3 and B2 less than 50% of the 5-HT cells colocalised leptin receptor immunoreactivity. Brainstem and diencephalic (catecholaminergic) neurons were identified by tyrosine hydroxylase immunocytochemistry and classified according to standard nomenclature. Within the periventricular hypothalamic dopaminergic nuclei A14 and A12, the metencephalic noradrenergic A6, A7, A2, A1, and the adrenergic C3, C2 and C1 cell groups, nearly all ty...Continue Reading

Citations

Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Claudia von MeyenburgBrian J Hrupka
Jul 23, 2003·Regulatory Peptides·Mônica Marques TellesEliane Beraldi Ribeiro
Aug 23, 2003·Neurobiology of Learning and Memory·Rie OhtaYuzo Ninomiya
Mar 10, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A C ShinP S MohanKumar
Feb 1, 2007·Nutritional Neuroscience·Helena PinosEsther Pérez-Torrero
Jun 12, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Bernard Thorens, Philip Just Larsen
Jun 12, 2002·Canadian Journal of Physiology and Pharmacology·James E BlevinsDenis G Baskin
Nov 28, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Diana L WilliamsDenis G Baskin
Jan 1, 2011·Schizophrenia Research and Treatment·Fabio PanarielloAndrea de Bartolomeis
Sep 15, 2014·Journal of Chemical Neuroanatomy·Nobuhiro WadaSeiji Shioda
Jun 3, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Olga O YevtushenkoGavin P Reynolds
Mar 22, 2012·Obesity Facts·Miriam GranadoJulie A Chowen
Nov 26, 2010·Journal of Clinical Psychopharmacology·Jochem G GregoorJan van der Weide
Oct 6, 2010·The Journal of Cell Biology·Patricia Ducy, Gerard Karsenty
Sep 19, 2008·Stress : the International Journal on the Biology of Stress·Akio KawakamiTatsushi Onaka
Oct 18, 2008·Behavioural Brain Research·Suresh AmbatiClifton A Baile
Apr 22, 2008·Pharmacology, Biochemistry, and Behavior·G D GamaroC Dalmaz
Jan 30, 2007·Pharmacology, Biochemistry, and Behavior·Shoko HiranoJunzo Kamei
Sep 23, 2008·The Journal of Comparative Neurology·Christoph RummelGiamal N Luheshi
Mar 10, 2010·Brain Research·María Carmen Fernández-GalazLuis M Garcia-Segura
Sep 20, 2006·Neuron·Stephanie FultonJeffrey S Flier
Mar 23, 2013·Regulatory Peptides·Mônica Marques TellesEliane Beraldi Ribeiro
Sep 15, 2014·Behavioural Brain Research·Jörg-Peter Voigt, Heidrun Fink
Jun 21, 2006·Journal of Psychopharmacology·Gavin P ReynoldsShona L Kirk
Oct 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kimberly A ClarkP S MohanKumar
Jan 18, 2002·Endocrinology·Kate L J EllacottSimon M Luckman
Aug 24, 2002·Endocrinology·Toru HosoiYasuyuki Nomura
Apr 16, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James W ManiscalcoLinda Rinaman
Mar 20, 2019·Nutrition & Diabetes·Andrew C ShinPuliyur S MohanKumar
Nov 14, 2019·International Journal of Molecular Sciences·Thomas Ho-Yin LeeSuk-Yu Yau
Sep 21, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Andrew C ShinPuliyur S MohanKumar

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