Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Kazuko MasuoMurray D Esler

Abstract

Leptin plays a key role in the regulation of body weight through the sympathetic nervous system; however, the contributions of leptin-receptor polymorphisms to obesity and sympathetic nerve activity have not been fully clarified. In the present study, we examined the relationships between leptin-receptor polymorphisms, plasma leptin and whole-body norepinephrine (NE) spillover as an index of sympathetic nerve activity in a Caucasian male cohort. In 129 young healthy normotensive men with a wide range of body mass index (BMI) (19.4-39.5 kg/m(2)), we measured leptin-receptor polymorphisms (Gln223Arg, Lys656Asn, and Lys109Arg), plasma leptin levels, whole-body NE spillover, whole-body NE clearance, BMI and blood pressure (BP) levels in the supine position after overnight fasting. Overweight-obese (BMI>or=25 kg/m(2)) subjects had significantly greater BMI, BP levels, plasma leptin and whole-body NE spillover compared to lean (BMI<25 kg/m(2)) subjects, but the NE clearance was similar. Overweight-obese subjects had significantly higher frequencies of the Arg223 allele and the Arg223 homozygous allele of Gln223Arg and the Asn656 allele of Lys656Asn compared to lean subjects. Subjects carrying the Arg223 homozygous or the Asn656 allel...Continue Reading

References

Jul 28, 1995·Science·M A PelleymounterF Collins
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Apr 25, 1996·Nature·S CollinsR S Surwit
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·L A CampfieldP Burn
Jul 15, 1997·The Journal of Clinical Investigation·W G HaynesW I Sivitz
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·J L HalaasJ M Friedman
Feb 12, 1998·The Journal of Clinical Investigation·C A Siegrist-KaiserC A Meier
Feb 7, 1998·Hypertension·E W ShekJ E Hall
Oct 2, 1998·The American Journal of Physiology·M A PelleymounterM McCaleb
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Apr 8, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·Y C ChagnonC Bouchard
May 20, 2000·Hypertension·K MasuoM L Tuck
Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·C J HukshornL A Campfield
May 22, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M WautersC Bouchard
Jun 20, 2001·American Journal of Hypertension·K MasuoM L Tuck
May 15, 2002·Obesity Research·Machteld WautersLuc F Van Gaal
Jun 22, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C J HukshornW H M Saris
Mar 29, 2003·The American Journal of Clinical Nutrition·Chris J HukshornWim H M Saris
Apr 22, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M MarsF J Kok
Jun 22, 2005·Seminars in Vascular Medicine·Robert V Considine
Jun 24, 2005·American Journal of Epidemiology·Valentina ParacchiniEmanuela Taioli
Jun 29, 2005·Diabetes·Kamal RahmouniWilliam G Haynes
Aug 11, 2005·The Journal of Clinical Endocrinology and Metabolism·Nora E StraznickyPaul J Nestel
Oct 10, 2006·American Journal of Hypertension·Kazuko MasuoMichael L Tuck
Mar 24, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideki KawaguchiMichael L Tuck

❮ Previous
Next ❯

Citations

Apr 7, 2009·Metabolic Syndrome and Related Disorders·Maria Gabriela Valle GottliebIvana Beatrice Manica da Cruz
Sep 9, 2016·Indian Journal of Clinical Biochemistry : IJCB·Apurva SrivastavaBalraj Mittal
Jul 18, 2009·Archives of Medical Research·Iztiar AbeteJ Alfredo Martínez
May 12, 2009·Archives of Medical Research·Samir Ben AliNaziha Kaabachi
Jan 31, 2013·Annals of the New York Academy of Sciences·Qianghua Xia, Struan F A Grant
Sep 16, 2011·Journal of the Science of Food and Agriculture·Yong-Bum SongYoung-Sook Kim
Aug 22, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kamal Rahmouni
Jan 22, 2013·Trends in Neurosciences·Stephanie E Simonds, Michael A Cowley
Apr 15, 2014·Physiology & Behavior·Haitao PanZhengquan Su
Jun 13, 2018·International Journal of Experimental Pathology·Zayani NesrineBouslama Ali
Jun 23, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomohiro KatsuyaToshio Ogihrara
Jul 26, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allyn L Mark
May 15, 2015·The Journal of Nutrition·Hua ZhaoXin Gen Lei
Jun 20, 2017·Journal of the American College of Nutrition·Francesco SavinoLeandra Silvestro
Jun 6, 2021·Clinics and Research in Hepatology and Gastroenterology·Amal Ahmed MohamedHanan M Fouad
Aug 5, 2021·Experimental and Therapeutic Medicine·Hanlin ZhangXiaomeng Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.