Leptin regulates the pro-inflammatory response in human epidermal keratinocytes

Archives of Dermatological Research
Moonyoung LeeMinsoo Noh

Abstract

The role of leptin in cutaneous wound healing process has been suggested in genetically obese mouse studies. However, the molecular and cellular effects of leptin on human epidermal keratinocytes are still unclear. In this study, the whole-genome-scale microarray analysis was performed to elucidate the effect of leptin on epidermal keratinocyte functions. In the leptin-treated normal human keratinocytes (NHKs), we identified the 151 upregulated and 53 downregulated differentially expressed genes (DEGs). The gene ontology (GO) enrichment analysis with the leptin-induced DEGs suggests that leptin regulates NHKs to promote pro-inflammatory responses, extracellular matrix organization, and angiogenesis. Among the DEGs, the protein expression of IL-8, MMP-1, fibronectin, and S100A7, which play roles in which is important in the regulation of cutaneous inflammation, was confirmed in the leptin-treated NHKs. The upregulation of the leptin-induced proteins is mainly regulated by the STAT3 signaling pathway in NHKs. Among the downregulated DEGs, the protein expression of nucleosome assembly-associated centromere protein A (CENPA) and CENPM was confirmed in the leptin-treated NHKs. However, the expression of CENPA and CENPM was not coupl...Continue Reading

References

Jan 26, 1991·Lancet·J N BarkerB J Nickoloff
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Aug 18, 2000·The Journal of Surgical Research·H O RennekampffJ M Schröder
Aug 23, 2000·The Journal of Clinical Investigation·S FrankJ Pfeilschifter
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·M G TonnesenR A Clark
Jul 10, 2001·The Journal of Investigative Dermatology·B StallmeyerS Frank
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·A GlasowJ Kratzsch
Mar 12, 2002·The Journal of Investigative Dermatology·M IguchiH Tagami
Nov 7, 2002·Cell·Shu TakedaGerard Karsenty
Aug 19, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ali MuradM Rocío Sierra-Honigmann
Apr 28, 2005·Nature Neuroscience·Heike Münzberg, Martin G Myers
Mar 16, 2006·Trends in Pharmacological Sciences·Frank PeelmanRalf Jockers
May 25, 2006·Journal of the American Dietetic Association·Veronica MontiTed D Adams
Dec 13, 2006·The Journal of Investigative Dermatology·Kathleen C Lee, Richard L Eckert
Feb 15, 2007·The Journal of Investigative Dermatology·Sabine A EmingJeffrey M Davidson
May 17, 2007·Journal of the American Academy of Dermatology·Gil YosipovitchAerlyn Dawn
May 16, 2008·Nature·Geoffrey C GurtnerMichael T Longaker
Jun 13, 2008·The British Journal of Dermatology·A JohnstonH Valdimarsson
Jul 22, 2008·The British Journal of Dermatology·A A CermanT Ergun
Nov 20, 2008·The British Journal of Dermatology·K S AndersonC Enerbäck
Jul 16, 2009·Experimental Dermatology·Burkhard PoeggelerRalf Paus
Feb 9, 2010·Journal of Dental Research·S Guo, L A Dipietro
Mar 27, 2010·Rheumatology·Helen L WrightSteven W Edwards
Feb 16, 2011·The Journal of Cell Biology·Francis Rodier, Judith Campisi
Feb 22, 2011·Cell·Ben E Black, Don W Cleveland
Apr 22, 2011·Nature Reviews. Molecular Cell Biology·Jolien S Verdaasdonk, Kerry Bloom
May 14, 2011·The British Journal of Dermatology·A R Shipman, G W M Millington
Apr 12, 2014·Nature Reviews. Immunology·Manolis PasparakisFrank O Nestle
Jul 27, 2014·The Journal of Endocrinology·Michael Rosenbaum, Rudolph L Leibel
Nov 22, 2014·Nature Reviews. Molecular Cell Biology·Caroline BonnansZena Werb
Dec 17, 2014·Metabolism: Clinical and Experimental·Neira SáinzJosé Alfredo Martínez
Jan 17, 2015·Biomolecules & Therapeutics·Ok-Nam BaeTae Cheon Jeong

❮ Previous
Next ❯

Citations

Jun 30, 2018·Endocrinology·Katie K Crean-Tate, Ofer Reizes
Feb 27, 2019·Archives of Dermatological Research·Jakub ŻółkiewiczLidia Rudnicka
Oct 4, 2020·Lipids in Health and Disease·Klaudia DopytalskaIrena Walecka
Dec 3, 2020·International Journal of Molecular Sciences·Dóra KovácsDániel Törőcsik
Jan 13, 2021·Archives of Dermatological Research·Anna StochmalLidia Rudnicka
Jan 25, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xin SuBin Wang
Feb 19, 2021·Frontiers in Immunology·Xin SuDong Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.