Leptin secretory dynamics and associated disordered eating psychopathology across the weight spectrum

European Journal of Endocrinology
Charumathi BaskaranElizabeth A Lawson

Abstract

Leptin secretory dynamics across the weight spectrum and their relationship with disordered eating psychopathology have not been studied. Our objective was to compare leptin secretory dynamics in 13 anorexia nervosa (AN), 12 overweight/obese (OB) and 12 normal-weight women using deconvolution analysis. In this cross-sectional study conducted at a tertiary referral center, serum leptin levels were obtained every 20  min from 2000 to 0800  h. Dual energy X-ray absorptiometry was used to measure percent body fat. Disordered eating psychopathology was assessed by the Eating Disorders Examination-Questionnaire (EDE-Q) and the Eating Disorders Inventory-2 (EDI-2). The groups differed for basal leptin secretion (BASAL) (P=0.02). Mean leptin pulse amplitude, pulse mass, total pulsatile secretion (TPS) and area under the curve (AUC) were significantly different between groups before and after adjustment for BASAL (P<0.0001 for all). Leptin AUC correlated strongly with TPS (r=0.97, P<0.0001) and less with BASAL (r=0.35, P=0.03). On multivariate analysis, only TPS was a significant predictor of leptin AUC (P<0.0001). TPS was inversely associated with most EDE-Q and EDI-2 parameters and the associations remained significant for EDE-Q eatin...Continue Reading

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Citations

Jan 4, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·M SykJ L Cunningham
Jun 1, 2016·PloS One·Vibha SinghalMadhusmita Misra
Dec 19, 2017·Global Heart·Jeffrey I MechanickW Timothy Garvey
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Jun 8, 2017·The Journal of Clinical Endocrinology and Metabolism·Melanie SchorrElizabeth A Lawson
Jun 27, 2020·World Journal of Gastroenterology : WJG·Umair KamranAndrew Holt

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