Leptin signaling as a therapeutic target of obesity

Expert Opinion on Therapeutic Targets
Neira SáinzMaría J Moreno-Aliaga

Abstract

Leptin is a hormone with a key role in food intake and body weight homeostasis. Congenital leptin deficiency (CLD) is a rare disease that causes hyperphagia and early severe obesity. However, common obesity conditions are associated with hyperleptinemia and leptin resistance. The main signaling pathways activated by leptin as well as the mechanisms underlying the regulatory actions of leptin on food intake and on lipid and glucose metabolism are reviewed. The potential mechanisms involving leptin resistance and the main regulatory hormonal and nutritional factors controlling leptin production/functions are also analyzed. The pathophysiology of leptin in human obesity, and especially the trials analyzing effects of leptin replacement therapy in patients with CLD or in subjects with common obesity and in post-obese weight-reduced subjects are also summarized. The use of drugs or specific bioactive food components with anti-inflammatory properties to reduce the inflammatory state associated with obesity, especially at the hypothalamus, may help to overcome leptin resistance. Research should also be focused on investigating dietary strategies, food supplements or drugs capable of avoiding or reversing the leptin fall during weight ...Continue Reading

References

Jul 28, 1995·Science·M A PelleymounterF Collins
Oct 10, 1997·Endocrinology·H F Escobar-MorrealeG Morreale de Escobar
Feb 12, 1998·The Journal of Clinical Investigation·T G KirchgessnerG S Hotamisligil
Dec 17, 1997·Biochemical and Biophysical Research Communications·G FrühbeckJ A Martínez
Mar 21, 1998·Nature Genetics·A StrobelA D Strosberg
Mar 26, 1998·Biochemical and Biophysical Research Communications·M YamaguchiY Murata
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·E IoffeJ M Friedman
Mar 27, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R B CeddiaR Curi
Sep 16, 1999·The New England Journal of Medicine·I S FarooqiS O'Rahilly
Nov 5, 1999·JAMA : the Journal of the American Medical Association·S B HeymsfieldM McCamish
Mar 14, 2000·Vitamins and Hormones·B Meister
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·P WellhoenerA Peters
Jul 6, 2000·Journal of Physiology and Biochemistry·J A MartínezG Frühbeck
Nov 25, 2000·Metabolism: Clinical and Experimental·R L MartinW J Millard
Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·C J HukshornL A Campfield
May 9, 2001·Biochemical and Biophysical Research Communications·M J Moreno-AliagaP J Havel
Aug 2, 2001·The Journal of Endocrinology·C MenendezF F Casanueva
Sep 22, 2001·The American Journal of Clinical Nutrition·M S Westerterp-PlantengaL A Campfield
Oct 26, 2001·Nature·K D NiswenderM W Schwartz
Nov 2, 2001·Nature·I S FarooqiS O'Rahilly
Dec 1, 2001·Reviews in Endocrine & Metabolic Disorders·R V Considine
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Michael RosenbaumRudolph L Leibel
Jun 22, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C J HukshornW H M Saris
Aug 7, 2002·The Journal of Nutrition·Elodie Peyron-CasoSalwa W Rizkalla
Jan 28, 2003·Biochemical Society Transactions·Y Minokoshi, B B Kahn
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Camilla HoldstockF Anders Karlsson
Jan 30, 2004·Recent Progress in Hormone Research·Martin G Myers
Mar 6, 2004·Journal of Physiology and Biochemistry·P Pérez-MatuteM J Moreno-Aliaga
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Julio LicinioMa-Li Wong
Apr 28, 2004·Diabetes·William A BanksJohn E Morley
Aug 5, 2004·Journal of Molecular Endocrinology·R-Y LiJ-L Chen

❮ Previous
Next ❯

Citations

May 29, 2016·Biochemical and Biophysical Research Communications·Yuling LianWenjun Wang
Oct 16, 2016·Journal of the American College of Cardiology·Jeffrey I MechanickW Timothy Garvey
Sep 9, 2016·Journal of Cellular Physiology·Miguel López-YoldiMaria J Moreno-Aliaga
Oct 5, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Pawel SzulcVéronique Breuil
Dec 14, 2018·European Journal of Nutrition·Kunfang GuXiubo Jiang
Jun 27, 2020·International Journal of Molecular Sciences·Shih-Yi LinChun-Jung Chen
Jun 14, 2019·Journal of Diabetes Research·Luis Rodrigo CataldoJosé L Santos
Mar 28, 2017·Journal of Developmental Origins of Health and Disease·S A SegoviaC M Reynolds
Mar 9, 2017·Pharmacological Reports : PR·Iván PatracaJaume Folch
Feb 6, 2020·Molecular Medicine Reports·Yuling LianWenjun Wang
May 1, 2017·Pharmacological Reports : PR·Iván PatracaJaume Folch
May 17, 2017·Acta histochemica·Fabiane Ferreira MartinsCarlos Alberto Mandarim-de-Lacerda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Bulletin de l'Académie nationale de médecine
Arnaud Basdevant, Cécile Ciangura
The American Journal of Clinical Nutrition
Susann Blüher, Christos S Mantzoros
The American Journal of Clinical Nutrition
I Sadaf Farooqi, Stephen O'Rahilly
The Journal of Endocrinology
Sharon H Chou, Christos S Mantzoros
Frontiers in Neuroendocrinology
Tina A DardenoChristos S Mantzoros
© 2022 Meta ULC. All rights reserved