PMID: 9525825Apr 3, 1998Paper

Leptomeningeal metastases: evaluation by gadolinium enhanced spinal magnetic resonance imaging

Journal of Neuro-oncology
J M GomoriT Siegal

Abstract

Leptomeningeal metastases are common in patients with metastatic systemic cancer or certain primary brain tumors. They may be unsuspected clinically and may be missed by cerebrospinal fluid (CSF) cytology. We undertook a retrospective study of the diagnostic value of gadolinium enhanced spinal MR imaging in patients with known or at high risk for leptomeningeal metastases (LM). Ninety-six gadolinium enhanced MR examinations of the whole spine were performed in 61 patients (26 primary central nervous system tumors, 20 solid tumors and 15 lymphoproliferative neoplasms). All patients had detailed neurological evaluation and concomitant CSF examination. Sixty-one MR's (62%) were positive, mostly in the lumbar spine. MR's were positive in 92% of patients with positive initial CSF cytology and in 60% of patients with negative CSF cytology. The MR examination was positive in 49% of those without clinical findings related to the spinal region. It showed disease beyond the symptomatic level in 42% of patients with spinal symptomatology. Multi-level spinal involvement was present in 57% of positive MR exams. Enhanced spinal MR is sensitive for the detection of neoplastic spinal seeding. It detects LM in about 50% of high risk patients wi...Continue Reading

Citations

Jan 15, 2011·Journal of Neuro-oncology·Carla Rameri Alexandre Silva de AzevedoDaniel Luiz Gimenes
Feb 3, 2012·Arquivos de neuro-psiquiatria·Sandro José MartinsDaniel Luiz Gimenes
May 16, 2000·Cancer Investigation·S A Jeyapalan, T T Batchelor
Nov 6, 2018·Case Reports in Obstetrics and Gynecology·Yasuyuki KawagoeHiroshi Sameshima
Apr 4, 2002·Clinical Pharmacokinetics·Tali Siegal, Ester Zylber-Katz
Oct 11, 2005·Journal of Neuro-oncology·Marc C ChamberlainLauren E Abrey
Dec 22, 2004·Current Oncology Reports·Marc C Chamberlain

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
P ElliottM H Werner
Pediatrics International : Official Journal of the Japan Pediatric Society
Luciana PortoRichard Du Mesnil
Journal of Computer Assisted Tomography
D M YousemR I Grossman
© 2022 Meta ULC. All rights reserved