Leptospira Genomospecies and Sequence Type Prevalence in Small Mammal Populations in Germany

Vector Borne and Zoonotic Diseases
Stefan FischerR G Ulrich

Abstract

Leptospirosis is a worldwide emerging infectious disease caused by zoonotic bacteria of the genus Leptospira. Numerous mammals, including domestic and companion animals, can be infected by Leptospira spp., but rodents and other small mammals are considered the main reservoir. The annual number of recorded human leptospirosis cases in Germany (2001-2016) was 25-166. Field fever outbreaks in strawberry pickers, due to infection with Leptospira kirschneri serovar Grippotyphosa, were reported in 2007 and 2014. To identify the most commonly occurring Leptospira genomospecies, sequence types (STs), and their small mammal host specificity, a monitoring study was performed during 2010-2014 in four federal states of Germany. Initial screening of kidney tissues of 3,950 animals by PCR targeting the lipl32 gene revealed 435 rodents of 6 species and 89 shrews of three species positive for leptospiral DNA. PCR-based analyses resulted in the identification of the genomospecies L. kirschneri (62.7%), Leptospira interrogans (28.3%), and Leptospira borgpetersenii (9.0%), which are represented by four, one, and two STs, respectively. The average Leptospira prevalence was highest (∼30%) in common voles (Microtus arvalis) and field voles (Microtus...Continue Reading

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Citations

Nov 18, 2018·Transboundary and Emerging Diseases·Kathrin JeskeRainer G Ulrich
Feb 1, 2019·Transboundary and Emerging Diseases·Anahi S VieiraWalter Lilenbaum
Feb 6, 2020·Vector Borne and Zoonotic Diseases·Stefan FischerRainer G Ulrich
Apr 25, 2020·Virus Genes·Florian BinderRainer G Ulrich
Nov 20, 2019·Emerging Infectious Diseases·Reimar JohneRainer G Ulrich
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Dec 22, 2020·Frontiers in Veterinary Science·Luciana Dos Santos MedeirosWalter Lilenbaum
Feb 4, 2021·Transboundary and Emerging Diseases·Kathrin JeskeStephan Drewes
Feb 23, 2021·Epidemiology and Infection·K JeskeC Imholt
May 1, 2021·Animals : an Open Access Journal From MDPI·Ivana PireddaValentina Chisu

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Methods Mentioned

BETA
dissection
PCR

Software Mentioned

multcomp
R
lsmeans
R Core Team

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