Leptospira interrogans requires heme oxygenase for disease pathogenesis

Microbes and Infection
Gerald L MurrayBen Adler

Abstract

We recently characterised the Leptospira interrogans heme oxygenase (hemO) gene and showed that HemO was required for growth with hemoglobin as the sole iron source. Here we investigated the role of HemO in pathogenesis. Hamsters inoculated with the hemO mutant showed 83% survival, compared with 33% for a control mutant (intergenic transposon insertion). Lung pathology was consistent with survival data, showing that HemO contributes significantly to pathogenesis and heme is a major in vivo iron source for L. interrogans. This is only the second defined, attenuated mutant in pathogenic Leptospira and the first to define function of the mutated gene.

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Citations

Sep 17, 2009·Nature Reviews. Microbiology·Albert I KoMathieu Picardeau
May 29, 2009·The Journal of Biological Chemistry·Yi-Pin LinYung-Fu Chang
Jan 12, 2011·The Journal of Infectious Diseases·Amporn SrikramGerald L Murray
Aug 29, 2012·Infection and Immunity·Azad EshghiCaroline E Cameron
Apr 9, 2010·Journal of Clinical Microbiology·Gerald L MurrayBen Adler
Mar 30, 2011·PloS One·Gustavo M CerqueiraAna L T O Nascimento
Aug 6, 2014·Biochimica Et Biophysica Acta·Anabel SoldanoDaniela L Catalano-Dupuy
Mar 29, 2011·Veterinary Microbiology·Ben AdlerGerald L Murray
Apr 7, 2009·Veterinary Microbiology·Ben Adler, Alejandro de la Peña Moctezuma
Dec 5, 2012·Veterinary Microbiology·Gerald L Murray
Jul 8, 2014·Veterinary Microbiology·Ben Adler
Aug 15, 2015·PLoS Neglected Tropical Diseases·Suneel A NarayanavariJames Matsunaga
Jul 9, 2016·PLoS Neglected Tropical Diseases·Heather S HermanJulia L Finkelstein
Apr 11, 2018·Molecular Microbiology·Jun-Jie ZhangX Frank Yang
May 20, 2015·Infection and Immunity·Azad EshghiMathieu Picardeau
Dec 25, 2013·Infection and Immunity·Amy M KingGerald L Murray
Apr 2, 2014·Infection and Immunity·Azad EshghiMathieu Picardeau
Sep 3, 2010·Molecular Microbiology·Gerald L MurrayBen Adler
Jun 10, 2015·Acta Crystallographica. Section D, Biological Crystallography·Isabelle MirasMathieu Picardeau
Mar 7, 2017·Nature Reviews. Microbiology·Mathieu Picardeau
Apr 20, 2018·International Journal of Molecular Sciences·Joanna KrajewskaSabina Kędzierska-Mieszkowska
Jul 5, 2018·Frontiers in Cellular and Infection Microbiology·Kristin V Lyles, Zehava Eichenbaum
Feb 26, 2020·Journal of Feline Medicine and Surgery·Andrea MurilloJosep Pastor
Apr 21, 2021·Microbial Pathogenesis·Charles Solomon Akino Mercy, Kalimuthusamy Natarajaseenivasan

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