Lesion analysis of cortical regions associated with the comprehension of Nonreversible and Reversible yes/no questions.

Neuropsychologia
David RaceArgye E Hillis

Abstract

We investigated the association between yes/no sentence comprehension and dysfunction in anterior and posterior left-hemisphere cortical regions in acute stroke patients. More specifically, we manipulated whether questions were Nonreversible (e.g., Are limes sour?) or Reversible (e.g., Is a horse larger than a dog?) to investigate the regions associated with semantic and syntactic processing. In addition, we administered lexical tasks (i.e., Picture-Word Verification, Picture Naming) to help determine the extent to which deficits in sentence processing were related to deficits in lexical processing. We found that errors on the lexical tasks were associated with ischemia in posterior-temporal Brodmann Areas (BA 21, 22, 37) and inferior parietal regions (BA 39, 40). Nonreversible question comprehension was associated with volume of tissue dysfunction, while Reversible question comprehension was associated with posterior regions (BA 39, 40) as well as one anterior region (BA 6). We conclude that deficits in Nonreversible questions required extensive dysfunction that affected language processing across multiple levels, while Reversible question comprehension was associated with regions involved in semantics as well as working memor...Continue Reading

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Citations

Dec 22, 2015·Brain and Language·David CaplanNikos Makris
Jun 1, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Laura M Skipper-KallalIngrid R Olson
Jun 17, 2015·Current Neurology and Neuroscience Reports·Donna C Tippett
Sep 16, 2014·Aphasiology·Corinne Pettigrew, Argye E Hillis
Oct 25, 2017·Journal of Cognitive Neuroscience·Corianne RogalskyGregory Hickok
Nov 2, 2019·Cerebral Cortex·William Matchin, Gregory Hickok
Oct 10, 2019·Journal of Cognitive Neuroscience·Sigfus KristinssonJulius Fridriksson
Oct 21, 2017·Language, Cognition and Neuroscience·Stephen M Wilson
Jul 6, 2019·Neurocase·Maria VarkanitsaHans Van de Koot
Jul 18, 2017·F1000Research·Donna C Tippett, Argye E Hillis
Jun 27, 2019·Cognitive, Affective & Behavioral Neuroscience·Daniel MirmanMyrna F Schwartz

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