Lesion complexity determines arterial drug distribution after local drug delivery.

Journal of Controlled Release : Official Journal of the Controlled Release Society
A R TzafririE R Edelman

Abstract

Though stents are deployed in diseased arteries drug distribution has only been quantified in intact, non-diseased vessels. We correlated steady-state arterial drug distribution with tissue ultrastructure and composition in abdominal aortae from atherosclerotic human autopsy specimens and rabbits with lesions induced by dietary manipulation and controlled injury. Paclitaxel, everolimus, and sirolimus depositions in the human aortae were maximal in the media and scaled inversely with lipid content. Net tissue paclitaxel and everolimus levels were indistinguishable in mildly injured rabbit arteries independent of diet. Yet, serial sectioning of cryopreserved arterial segments demonstrated a differential transmural deposition pattern that was amplified with disease and correlated with the expression of their intracellular targets, tubulin and FKBP-12. Tubulin distribution and paclitaxel binding increased with vascular injury and macrophage infiltration, and were reduced with lipid content. Sirolimus analogs and their specific binding target FKBP-12 were less sensitive to alterations of diet in mildly injured arteries, presumably reflecting a faster transient response of FKBP-12 to injury. The data demonstrate that disease-induced ...Continue Reading

References

Feb 1, 1977·Circulation Research·R L BratzlerR S Lees
May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·C A RamirezR S Lees
Apr 1, 1994·Journal of the American College of Cardiology·R Riessen, J M Isner
Oct 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·C RogersE R Edelman
Jun 1, 1997·Journal of the American College of Cardiology·M A LovichE R Edelman
Aug 3, 1999·Journal of Pharmaceutical Sciences·W K WanE R Edelman
Apr 29, 2000·Circulation Research·C J CreelE R Edelman
Jun 7, 2000·Journal of the American College of Cardiology·C HerdegK R Karsch
Dec 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·F G WeltC Rogers
Dec 29, 2000·Journal of the American College of Cardiology·D E DrachmanC Rogers
Oct 3, 2002·Circulation·Robert S SchwartzUNKNOWN Consensus Committee
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Frederick G P Welt, Campbell Rogers
Jul 18, 2003·Vascular Medicine·Frederick G P WeltCampbell Rogers
Jun 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew D LevinElazer R Edelman
Mar 30, 2005·Circulation·Chao-Wei HwangElazer R Edelman
Nov 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andrew D LevinElazer R Edelman
Nov 15, 2006·The New England Journal of Medicine·Edoardo Camenzind
Feb 14, 2007·The New England Journal of Medicine·Bo LagerqvistUNKNOWN SCAAR Study Group
May 19, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
Jul 10, 2007·Journal of the American College of Cardiology·David R HolmesMitchell W Krucoff
Sep 18, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Brinda BalakrishnanElazer R Edelman
Feb 15, 2008·The New England Journal of Medicine·Gunnar TepeUlrich Speck
Jun 10, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Bruno SchellerUlrich Speck
Aug 21, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Brinda BalakrishnanElazer R Edelman
Oct 18, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vijaya B KolachalamaElazer R Edelman
Oct 1, 2008·Circulation. Cardiovascular Interventions·Robert S SchwartzRobert L Wilensky

❮ Previous
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Citations

Sep 20, 2015·Annals of Biomedical Engineering·C M McKittrickC McCormick
Feb 24, 2012·Journal of Pharmaceutical Sciences·James J KleinedlerTammy R Dugas
Apr 10, 2013·Journal of Pharmaceutical Sciences·Ji GuoDinesh V Patwardhan
May 31, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abraham R TzafririElazer R Edelman
Jul 15, 2011·Revista española de cardiología·Mercedes Balcells, Elazer R Edelman
Dec 25, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anne SeidlitzWerner Weitschies
Jun 13, 2012·The Journal of Pharmacy and Pharmacology·Anne Seidlitz, Werner Weitschies
May 26, 2012·Small·Chang Kuk ChoiWon Hyoung Ryu
May 3, 2012·Annals of the New York Academy of Sciences·Jordi MartorellMercedes Balcells
Jan 24, 2015·European Journal of Clinical Investigation·Vivian G NgAlexandra J Lansky
Jul 21, 2015·Journal of Vascular and Interventional Radiology : JVIR·Rocío Fernández-ParraMiguel A de Gregorio
Jul 8, 2015·Therapeutic Delivery·Anne SeidlitzWerner Weitschies
Jul 12, 2014·Mathematical Biosciences·Sean McGinty
Feb 6, 2015·Journal of the Royal Society, Interface·Kumaran KolandaiveluVijaya B Kolachalama
Jul 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Farhad RikhtegarVartan Kurtcuoglu
Aug 25, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gordon Minru XiongYingying Huang
Feb 6, 2017·Annals of Biomedical Engineering·Georgia S KaranasiouDimitrios I Fotiadis
May 5, 2011·Circulation. Cardiovascular Interventions·Beau M Hawkins, Thomas A Hennebry
Apr 16, 2013·Circulation·Vijaya B KolachalamaElazer R Edelman
Jul 18, 2015·Annals of Biomedical Engineering·David M SaylorJames A Warren
May 7, 2020·Circulation·Krishna J Rocha-SinghUNKNOWN VIVA Physicians, Inc
Dec 12, 2019·Cardiovascular and Interventional Radiology·Konstantinos KatsanosDimitrios Karnabatidis
Jul 23, 2016·Cardiovascular Engineering and Technology·Prashanta K MandalVijaya B Kolachalama
Oct 18, 2020·Journal of Neurointerventional Surgery·Yabing WangLiqun Jiao
May 15, 2021·Journal of the American College of Cardiology·David Marlevi, Elazer R Edelman
Apr 4, 2021·Journal of Vascular and Interventional Radiology : JVIR·Konstantinos KatsanosStavros Spiliopoulos
Jul 31, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Konstantinos KatsanosDimitrios Karnabatidis
Oct 13, 2021·Drug Delivery and Translational Research·Ruyi ZhouYuqi Zhang
Dec 6, 2021·Advanced Healthcare Materials·Francesca RazziHeleen M M van Beusekom

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