Lesion detection and characterization in a breast US phantom: results of the ACRIN 6666 Investigators

Radiology
Wendie A BergACRIN 6666 Investigators

Abstract

To prospectively evaluate ultrasonographic (US) lesion detection and characterization in a breast phantom by potential investigators in a screening US protocol, American College of Radiology Imaging Network (ACRIN) 6666. National Cancer Institute Cancer Experimental Therapeutic Protocol review and ACRIN internal institutional review board approved the protocol; potential investigators were informed of the study purpose prior to participation. Six equivalent anthropomorphic phantoms were prepared with 17 masses (2-10 mm in mean diameter) in different locations at different depths. Sixty-six investigators, experienced in breast US, from 23 institutions scanned a phantom with high-frequency linear-array transducers (12-5 MHz). Lesion location, diameters, echogenicity, shape, and posterior features were recorded. Reader-specific phantom maps were generated and compared with known lesion locations and features. Results from 64 observers could be analyzed and were masked to investigator identity. Agreement on US features was measured with kappa statistics. A generalized linear model generated log relative risks for detection rates as a function of lesion diameter, depth, and features. Of 17 lesions, a median of 14 (82%) were detected...Continue Reading

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Citations

May 15, 2008·JAMA : the Journal of the American Medical Association·Wendie A BergUNKNOWN ACRIN 6666 Investigators
Oct 9, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Takayoshi Uematsu
May 22, 2009·AJR. American Journal of Roentgenology·Nathan BluvolAaron Fenster
Aug 25, 2011·AJR. American Journal of Roentgenology·Hee Jung ShinJeoung Hyun Kim
Apr 4, 2008·Medical Physics·Nathan BluvolAaron Fenster
Aug 8, 2008·Future Oncology·Vineeta SinghAnita Bourke
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Dec 30, 2015·Journal of the National Cancer Institute·Wendie A BergEtta D Pisano
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Sep 16, 2008·Academic Radiology·Nicholas P GruszauskasLorenzo L Pesce
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Jun 24, 2021·BMC Medical Imaging·Pascale Brasier-LutzRosanna Zanetti-Dällenbach

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