PMID: 9533396Apr 9, 1998Paper

Lesion-induced axon sprouting in the deafferented striatum of adult rat

Neuroscience Letters
H W ChengT H McNeill

Abstract

Synaptic replacement in rat striatum following a unilateral cortical lesion was investigated using electron microscopy and the anterograde tracer, biotinylated dextrin amine (BDA). In the deafferented striatum evidence of axon sprouting and synapse replacement was seen at 20 days after the lesion and most newly-formed axon terminals were labeled with BDA injected previously into the contralateral cortex. In addition, BDA-labeled fibers from the contralateral cortex formed multiple asymmetric axospinous synapses with deafferented striatal neurons, a morphological feature rarely seen in unlesioned rats. These data suggest that in response to a unilateral cortex lesion axons from the contralateral cortex sprout and reinnervated the deafferented striatal neurons and that reinnervation by 'like' afferents maybe crucial for the establishment of functional recovery after the unilateral cortex lesion.

References

Sep 22, 1987·The Journal of Comparative Neurology·C J Wilson
Sep 30, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M Kemp, T P Powell

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Citations

Jun 1, 2005·Brain Research. Molecular Brain Research·Guillaume HébertJacques Demotes-Mainard
Jul 6, 2000·Neuroscience·D I FinkelsteinM K Horne
Oct 10, 2002·The European Journal of Neuroscience·C L ParishM K Horne
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francesca MazzoniEnrica Strettoi
Dec 3, 2005·Experimental Neurology·Veronique Riban, Marie-Françoise Chesselet
Oct 4, 2011·Brain Research Bulletin·Christopher A Lieu, Thyagarajan Subramanian
Apr 7, 2005·Reviews in the Neurosciences·Màtè Daniel Döbrössy, Stephen B Dunnett
May 18, 2017·Neural Plasticity·Michael J HylinRyan Holden

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