PMID: 9447617Feb 3, 1998Paper

Lesion-induced plasticity of central neurons: sprouting of single fibres in the rat hippocampus after unilateral entorhinal cortex lesion

Progress in Neurobiology
T Deller, M Frotscher

Abstract

In response to a central nervous system trauma surviving neurons reorganize their connections and form new synapses that replace those lost by the lesion. A well established in vivo system for the analysis of this lesion-induced plasticity is the reorganization of the fascia dentata following unilateral entorhinal cortex lesions in rats. After general considerations of neuronal reorganization following a central nervous system trauma, this review focuses on the sprouting of single fibres in the rat hippocampus after entorhinal lesion and the molecular factors which may regulate this process. First, the connectivity of the fascia dentata in control animals is reviewed and previously unknown commissural fibers to the outer molecular layer and entorhinal fibres to the inner molecular layer are characterized. Second, sprouting of commissural and crossed entorhinal fibres after entorhinal cortex lesion is described. Single fibres sprout by forming additional collaterals, axonal extensions, boutons, and tangle-like axon formations. It is pointed out that the sprouting after entorhinal lesion mainly involves unlesioned fibre systems terminating within the layer of fibre degeneration and is therefore layer-specific. Third, molecular ch...Continue Reading

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Citations

Jul 2, 2005·Experimental Brain Research·Klaus Oliver SchubertMatthias Kirsch
Oct 7, 2009·Cell and Tissue Research·Bernd HeimrichMartin Schwemmle
Jun 11, 2005·Molecular and Cellular Neurosciences·Michael SchäferThomas Brümmendorf
Dec 12, 2003·Brain Research. Molecular Brain Research·Yan WangChangfu Zhou
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Sep 9, 2011·Journal of Neurophysiology·Fu-Sun LoReha S Erzurumlu
Jan 10, 2014·PloS One·Domenico Del TurcoThomas Deller
Aug 16, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Manuela PolydoroBradley T Hyman
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julia V PerederiyGary L Westbrook
Aug 24, 2010·Behavioural Brain Research·Julio J RamirezRonald L Klein
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Feb 3, 2005·Journal of Neurochemistry·Sophie B GaudreaultJudes Poirier
Aug 25, 2004·Journal of Neuroscience Methods·Guido J BurbachThomas Deller

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