Lesion-induced re-expression of neonatal recognition molecules in adult rat cerebellum

Brain Research Bulletin
S LehmannJ P Zanetta

Abstract

It has been previously shown that sectioning of parallel fibers in the cerebellar molecular layer of adult rats gave rise to rapid reinnervation of the target cells, i.e., Purkinje cells. This paper reports that such a reinnervation is accompanied by reexpression (partial and total) of two developmentally regulated complementary molecules. These are an endogenous mannose-binding lectin, called R1, which reappears at the surface of the dendrites of Purkinje cells, and an endogenous glycoprotein ligand of R1, the 31 kDa glycoprotein, which seems to be neosynthetized and transported to the surface of parallel fibers. In this system, embryonic N-CAM is not reexpressed in neurons but reappears in reactive astrocytes in the vicinity of the lesion. The reexpression of recognition molecules (lectin and glycoprotein ligand) involved in normal synaptogenesis, may constitute the molecular basis for repair of nervous circuits in the adult as well.

References

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S LehmannJ P Zanetta
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky

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Citations

Nov 1, 1992·The Histochemical Journal·J P ZanettaG Vincendon
Sep 1, 1995·Pediatric Neurology·M L Grunnet
Jan 21, 2000·Brain Research. Molecular Brain Research·C S RicardM R Hernandez
Apr 5, 2000·Progress in Retinal and Eye Research·M R Hernandez
Jan 10, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Phoebe H YagerMichael J Whalen
Apr 1, 1997·Experimental Neurology·O S JørgensenD G Stein
May 1, 1996·Neurochemical Research·D P WoldbyeO S Jørgensen

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