PMID: 2495844Feb 1, 1989Paper

Lesion-induced reductions in trace amine accumulation: dependence on MAO inhibitor pretreatment

Brain Research Bulletin
T V NguyenA J Greenshaw

Abstract

Striatal amine levels were measured six weeks after unilateral injections of 6-OHDA (8 micrograms) into the substantia nigra in male Wistar rats pretreated with monoamine oxidase inhibitors. After (-) deprenyl.HCl pretreatment (2 mg.kg-1 SC 2hr), beta-phenylethylamine, m- and p-tyramine ipsilateral to the 6-OHDA lesion decreased to 50, 18 and 25% of contralateral levels. DA, DOPAC and HVA also decreased on the lesioned side. Ipsilateral concentrations of tryptamine, 5-HT, 5-HIAA, p-tyrosine and L-tryptophan concentrations were equivalent to contralateral values in this condition. In animals pretreated with pargyline.HCl (200 mg.kg-1 IP 2hr) m- and p-tyramine and tryptamine ipsilateral to the lesion decreased to 48, 59 and 57% of contralateral levels. Ipsilateral DA decreased to 26% of the contralateral value. Under these conditions no change in concentrations of beta-phenylethylamine or of the above acid metabolites or amino acids was observed. The masking of lesion-induced changes in beta-phenylethylamine by pargyline is attributed to the lipophilic nature of of this molecule and consequent diffusion of this amine from other areas after maximal monoamine oxidase inhibition. Conversely the failure to demonstrate lesion-induced ...Continue Reading

References

Jul 1, 1979·Journal of Neurochemistry·S R Philips, A A Boulton
Jan 1, 1975·Canadian Journal of Biochemistry·S R PhilipsA A Boulton
Oct 10, 1975·Brain Research·A A BoultonP H Wu
Oct 1, 1986·Brain Research Bulletin·A J GreenshawT V Nguyen
Jan 1, 1988·Journal of Neural Transmission·S TurkishA J Greenshaw
Sep 1, 1974·Journal of Neurochemistry·J M SaavedraJ Axelrod
Jul 1, 1973·Canadian Journal of Biochemistry·D A DurdenA A Boulton
May 1, 1974·Canadian Journal of Biochemistry·S R PhilipsA A Boulton
Jun 1, 1974·Canadian Journal of Biochemistry·S R PhilipsA A Boulton
Jul 1, 1968·Biochemical Pharmacology·J P Johnston

❮ Previous
Next ❯

Citations

Sep 1, 1993·Neurochemical Research·P R PaetschA V Juorio
Sep 12, 2006·Progress in Neurobiology·Scott A Burchett, T Philip Hicks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.