PMID: 8950000Nov 1, 1996Paper

Lesion of the habenular efferent pathway produces anxiety and locomotor hyperactivity in rats: a comparison of the effects of neonatal and adult lesions

Behavioural Brain Research
C A MurphyM Murray

Abstract

Recent studies have implicated the habenula in modulating states of arousal and chronic responses to stress. We examined whether lesion of the habenula efferent pathway, the fasciculus retroflexus (FR), at either 3 (P3) or 70 (P70) days of age affects stress-related anxiety (elevated plus-maze test) and activity levels (open-field test) in rats tested as adults. Both P3- and P70-lesioned rats showed chronically elevated plasma levels of corticosterone. Rats receiving FR lesions as neonates (P3) exhibited greater open arm avoidance on the elevated plus-maze than controls 2 months postoperatively, suggesting a heightened state of anxiety. In contrast, P70-lesioned rats behaved similarly to controls on the plus-maze, but showed increased locomotion and increased grooming in the open field, effects not observed in P3-lesioned rats. When an additional stressful condition was imposed (5 days of social isolation plus 24 h food deprivation) before testing, both FR-lesion groups showed an attenuation of the normal behavioral responses (decreased open-arm entries/time in open arms, increased freezing). The effects of FR lesions on activity and behavioral indices of anxiety may be due to disruption of lateral habenular projections to dopa...Continue Reading

References

Aug 1, 1978·European Journal of Pharmacology·A R CoolsW H Gispen
Sep 1, 1979·The Journal of Comparative Neurology·M Herkenham, W J Nauta
Mar 1, 1991·Trends in Neurosciences·S Green
Jan 1, 1985·The Journal of Comparative Neurology·R Artymyshyn, M Murray
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·R A Shephard
Jan 1, 1988·Psychoneuroendocrinology·O G Cameron, R M Nesse
May 1, 1973·Animal Behaviour·J Archer
Mar 1, 1972·Journal of Comparative and Physiological Psychology·J R WilsonG W Van Hoesen
Jul 30, 1969·Annals of the New York Academy of Sciences·V H Denenberg
Aug 7, 1981·Neuroscience Letters·A LisoprawskiJ Glowinski
Jan 1, 1994·Psychopharmacology·S E FileP S Mabbutt
Oct 29, 1993·Annals of the New York Academy of Sciences·F MenzaghiG F Koob
Jul 30, 1993·Behavioural Brain Research·M C SilveiraF G Graeff
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·D TreitC Royan
Dec 1, 1992·Behavioural Processes·M E Albonetti, F Farabollini

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Citations

Aug 15, 2001·The Journal of Comparative Neurology·M GotoN S Canteras
Dec 10, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Isaac H Bianco, Stephen W Wilson
Jan 25, 2012·Progress in Neurobiology·L SheltonD Borsook
Jun 23, 2009·Neuroscience Letters·Yuhong WangWenhua Zhou
Jan 27, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Juan Francisco Rodríguez-LandaMargarita Saavedra
Mar 24, 2007·Neuroscience and Biobehavioral Reviews·Lucas Lecourtier, Peter H Kelly
Jun 6, 2009·The European Journal of Neuroscience·Baptiste LacosteLaurent Descarries
May 7, 2004·The European Journal of Neuroscience·Lucas LecourtierPeter H Kelly
Jul 23, 2011·The European Journal of Neuroscience·Matthew J PaulWilliam J Schwartz
Aug 24, 2013·Pharmacology, Biochemistry, and Behavior·Margaret J GillRonald E See
Apr 7, 2015·Neuropharmacology·Fengjiao ChenGang Peng
Jul 9, 2016·Alcoholism, Clinical and Experimental Research·Elizabeth J GloverL Judson Chandler
Aug 5, 2017·Journal of Medicinal Food·Socorro Herrera-MezaRosa María Oliart-Ros
Nov 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lucas Lecourtier, Peter H Kelly
May 25, 2007·Nature·Masayuki Matsumoto, Okihide Hikosaka
Oct 29, 2005·The Journal of Comparative Neurology·Thomas Jhou
Jun 3, 2020·Journal of Neuropathology and Experimental Neurology·Abigail Snyder-KellerLaura D Kramer
Oct 6, 2018·Proceedings of the National Academy of Sciences of the United States of America·Erica SeigneurThomas C Südhof
Nov 7, 2017·Seminars in Cell & Developmental Biology·Sara Roberson, Marnie E Halpern
Feb 23, 2017·Neuroscience and Biobehavioral Reviews·Marc Fakhoury

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