PMID: 9181435Jun 1, 1997Paper

Lesion of the serotonergic terminals in the suprachiasmatic nuclei limits the phase advance of body temperature rhythm in food-restricted rats fed during daytime

Journal of Biological Rhythms
Etienne ChalletA Malan

Abstract

The daily rhythm of body temperature was recorded in control rats fed ad libitum and subsequently fed during daytime 50% of ad libitum food intake. Aside from the expression of a feeding-associated component, body temperature rhythm was phase advanced (7 h) by a timed caloric restriction; the new plateau of the acrophase of the nocturnal peak was close to the light-dark transition. A lesion of serotonergic (5-HTergic) terminals in the suprachiasmatic nuclei (SCN)-the endogenous circadian clock(s)-was performed by microinjection of the 5-HT neurotoxin 5,7-dihydroxytryptamine (5,7-DHT). During the ad libitum-fed state, the acrophase of body temperature rhythm was not modified by the 5,7-DHT treatment. In response to a timed caloric restriction, however, the phase advance of the nocturnal peak of body temperature rhythm was reduced by 2 h in rats with 5,7-DHT lesions as compared to that of sham-operated rats. Magnitude and day-night pattern of wheel-running activity between the two groups of rats also were analyzed. No intergroup difference was found in the amount of wheel-running activity prior to the time of feeding. Moreover, the phase advance of nocturnal component of locomotor activity rhythm observed toward the time of feedi...Continue Reading

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Citations

Feb 23, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Etienne Challet
Feb 9, 2011·The European Journal of Neuroscience·Laurent NexonSylvie Raison
Mar 22, 2002·The European Journal of Neuroscience·Stéphane BarassinPaul Pévet
Dec 8, 2004·Physiology & Behavior·Marleen H M de Groot, Benjamin Rusak

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