Lesion progression and plaque composition are not altered in older apoE-/- mice lacking tumor necrosis factor-alpha receptor p55

Atherosclerosis
Erwin BlessingMichael E Rosenfeld

Abstract

Inflammatory processes are an integral component of the initiation, progression, and destabilization of atherosclerotic lesions. Tumor necrosis factor-alpha (TNF-alpha) is considered a primary mediator of inflammatory processes. The role of TNF-alpha in plaque progression and plaque destabilization was investigated in the innominate arteries of older TNF-alpha receptor p55 deficient mice that were generated on a hyperlipidemic apolipoprotein E deficient background (p55-/- apoE-/-). There were no significant differences in levels of circulating cytokines, plaque progression, plaque composition or features of plaque destabilization in p55-/- apoE-/- compared to wild type (p55+/+ apoE-/-) mice. Progression and destabilization of advanced atherosclerotic lesions does not seem to be mediated via the TNF-alpha receptor p55.

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Citations

May 20, 2008·Cardiovascular Research·Robert KleemannTeake Kooistra
Sep 9, 2005·Current Opinion in Lipidology·Sofia XanthouleaMenno P J de Winther
Apr 20, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Lisheng ZhangNeil J Freedman
Mar 22, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Lesca M HoldtDaniel Teupser
Nov 15, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Tomas KovarnikAles Linhart
Dec 8, 2011·Journal of Atherosclerosis and Thrombosis·Manabu KitagakiMakoto Kikuchi
Oct 24, 2008·The American Journal of Medicine·Peter Libby
Jan 1, 2008·Drug Discovery Today. Therapeutic Strategies·Macrae F Linton, Sergio Fazio
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Feb 16, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Unni M ChandrasekharanPaul E DiCorleto
May 20, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Christopher L Jackson
Mar 3, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Christopher L JacksonRob Krams
Sep 19, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Kitty SchapiraSylvia Heeneman

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