Lesion topographies in multiple sclerosis diagnosis: A reappraisal

Neurology
Georgina ArrambideX Montalbán

Abstract

To assess the contributions of cortico-juxtacortical and corpus callosum lesions to multiple sclerosis diagnosis and to compare the value of ≥1 vs ≥3 periventricular lesions in clinically isolated syndromes (CIS). Step 1: We evaluated lesion topography classifications in 657 patients with CIS with stepwise Cox proportional hazards regression models considering second attack as the outcome. Step 2: We established 2 dissemination in space (DIS) versions according to the periventricular lesion cutoffs of ≥1 and ≥3 and assessed their performance at 10 years with second attack as the outcome, first individually and then combined with dissemination in time (DIT) in all cases (n = 326), by age, and by CIS topography. Step 1: The models (hazard ratios [95% confidence interval]) favored ≥1 over ≥3 periventricular lesions (2.5 [1.7-3.6]) and cortico-juxtacortical over juxtacortical lesions (1.4 [1.0-1.8]). Callosal lesions were not selected. Step 2: DIS specificity with ≥1 periventricular lesions was slightly lower than with ≥3 (59.1 vs 61.4) and the same after adding DIT (88.6). Regarding age, ≥3 periventricular lesions improved DIS specificity over ≥1 lesions in the 40-49 years of age bracket (66.7 vs 58.3). This difference disappeared...Continue Reading

References

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Nov 26, 2010·Neurology·M TintoreX Montalban
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Sep 8, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Wallace J BrownleeDavid H Miller
Mar 17, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Georgina ArrambideMar Tintore
May 12, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Jae-Won HyunHo Jin Kim

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Citations

Oct 10, 2018·Current Opinion in Neurology·Jiwon OhXavier Montalban
Jun 5, 2019·Continuum : Lifelong Learning in Neurology·Andrew J Solomon
Nov 9, 2019·Expert Review of Neurotherapeutics·Georgina Arrambide, Mar Tintore
Nov 5, 2017·Neurology·Anders Svenningsson, Olga Ciccarelli
Oct 27, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D-H LeeR A Linker
Jun 27, 2019·Multiple Sclerosis Journal - Experimental, Translational and Clinical·T K BanerjeeS Purakayastha
May 28, 2020·Biomedicines·Mariano MarrodanJorge Correale
Jun 29, 2018·Current Opinion in Neurology·Massimo FilippiMaria A Rocca
Jan 3, 2021·Journal of Neurology·Zhizheng ZhuoYaou Liu

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Software Mentioned

SPSS Statistics
DIR
MAGNIMS

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