Lesional accumulation of CD163+ macrophages/microglia in rat traumatic brain injury

Brain Research
Zhiren ZhangHermann J Schluesener

Abstract

A robust neuroinflammation, contributing to the development of secondary injury, is a common histopathological feature of traumatic brain injury (TBI). Characterization of leukocytic subpopulations contributing to the early infiltration of the damaged tissue might aid in further understanding of lesion development. Reactive macrophages/microglia can exert protective or damaging effects in TBI. CD163 is considered a marker of M2 (alternatively activated) macrophages. Therefore we investigated the accumulation of CD163(+) macrophages/microglia in the brain of TBI rats. TBI was induced in rats using an open skull weight-drop contusion model and the accumulation of CD163(+) cells was analyzed by immunohistochemistry. In normal rat brains, CD163 was expressed by meningeal, choroid plexus and perivascular macrophages. Significant parenchymal CD163(+) cell accumulation was observed two days post TBI and continuously increased in the investigated survival time. The accumulated CD163(+) cells were mainly distributed to the lesional areas and exhibited macrophage phenotypes with amoeboid morphologic characteristics but not activated microglial phenotypes with hypertrophic morphology and thick processes. Double-labeling experiments showed...Continue Reading

References

Feb 1, 1979·Clinical Cardiology·J A ReiffelJ T Bigger
Mar 1, 1989·Journal of Periodontal Research·H H TopollC Sorg
Aug 1, 1996·Trends in Neurosciences·G W Kreutzberg
May 26, 1999·Progress in Neurobiology·G Stoll, S Jander
Feb 8, 2002·Molecular Neurobiology·P M LenzlingerT K McIntosh
Sep 17, 2002·Antioxidants & Redox Signaling·Shigeki ShibaharaKazuhiro Takahashi
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Oct 14, 2004·Annals of Medicine·Søren K Moestrup, Holger J Møller
Apr 27, 2005·Brain Research. Brain Research Reviews·Rune LadebyBente Finsen
May 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Edward F ChangLinda J Noble-Haeusslein
Aug 18, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T B KnudsenJ Eugen-Olsen
Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rohini PolavarapuManuel Yepes
Feb 16, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Peter UgocsaiGerd Schmitz
Mar 7, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoshihiro KomoharaMotohiro Takeya
Jul 13, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xiaohui ZhangManuel Yepes
Apr 27, 2007·Neuroscience·I GlezerS Rivest
May 17, 2007·Current Medicinal Chemistry·S Thameem DheenEng-Ang Ling
Apr 16, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Jun-ichi SatohHidehiko Konno
May 17, 2008·Journal of Leukocyte Biology·Timothy S Zheng, Linda C Burkly
Jul 23, 2008·Neuroscience·I Napoli, H Neumann
Sep 17, 2008·Journal of the Neurological Sciences·Ioana IntaMarkus Schwaninger
Oct 15, 2008·Neuroscience Letters·Ian GaleaTracey A Newman
Apr 22, 2009·Blood·Marianne Jensby Nielsen, Søren Kragh Moestrup
Aug 6, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Carol A Colton
Oct 13, 2009·Journal of Autoimmunity·Delisa Fairweather, Daniela Cihakova
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jenna M Ziebell, Maria Cristina Morganti-Kossmann
Feb 13, 2010·Annual Review of Physiology·Jerrold M Olefsky, Christopher K Glass
Mar 18, 2010·Nature Reviews. Neurology·V Hugh PerryClive Holmes
Mar 20, 2010·Molecular Immunology·Hanne Van GorpHans J Nauwynck
Jul 21, 2010·Biochemical Pharmacology·Ananta PaineStephan Immenschuh
Aug 14, 2010·Current Drug Targets·Agnieszka Jazwa, Antonio Cuadrado

❮ Previous
Next ❯

Citations

Jun 27, 2013·Molecular Neurobiology·Dah-Yuu LuYueh-Hsiung Kuo
Apr 26, 2014·Journal of Neuroinflammation·L Christine TurtzoJoseph A Frank
Jun 4, 2014·Journal of Neuroinflammation·Jonathan D CherryM Kerry O'Banion
Dec 4, 2013·Journal of Neurotrauma·Eric J NisenbaumYvonne W Lui
Jun 24, 2014·Acta Neuropathologica·Jeroen F J BogieJerome J A Hendriks
Mar 7, 2014·Antioxidants & Redox Signaling·Ana I RojoAntonio Cuadrado
Jan 22, 2013·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Atsushi SasakiHiroko Ohgaki
Jun 6, 2015·Molecular Nutrition & Food Research·Esther ParadaManuela G López
Dec 3, 2014·Neuroscience·M S Moehle, A B West
Jun 13, 2015·Progress in Neurobiology·Rafael Franco, Diana Fernández-Suárez
Aug 1, 2015·Molecular Neurobiology·Qian LiJian Wang
Aug 4, 2016·Frontiers in Molecular Biosciences·Alexander V GlushakovSylvain Doré
Mar 31, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jenna L LeclercSylvain Doré
Apr 6, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Arjang SalehiAndre Obenaus
Dec 5, 2017·Korean Journal of Neurotrauma·Hüseyin ÖzevrenŞenay Deveci
Jun 22, 2018·Nature Reviews. Neurology·Diederik BultersIan Galea
Aug 7, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Giuseppe FaracoCostantino Iadecola
Apr 9, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Elizabeth NewellRobert S B Clark
Oct 17, 2019·Molecular Neurobiology·Steven A RobicsekSylvain Doré
Feb 12, 2017·Nature Reviews. Neurology·Dennis W SimonPatrick M Kochanek
May 23, 2017·Frontiers in Immunology·Katalin LumniczkyGéza Sáfrány
Nov 22, 2019·CNS Neuroscience & Therapeutics·Tuo YangFeng Zhang
May 21, 2020·Acta Neuropathologica Communications·Liam KempthorneDennis W Dickson
Nov 23, 2016·Journal of Neurovirology·Yoelvis Garcia-MesaDavid Alvarez-Carbonell
Nov 3, 2020·Frontiers in Immunology·Tertia D Purves-TysonCynthia Shannon Weickert
Feb 25, 2020·Experimental Neurology·Eric E Abrahamson, Milos D Ikonomovic
Mar 23, 2021·Frontiers in Immunology·Daniela C IvanGiuseppe Locatelli
Apr 2, 2021·Frontiers in Cellular Neuroscience·Keith E Campagno, Claire H Mitchell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis